1000279-69-5Relevant articles and documents
Heteromeric neuronal nicotinic acetylcholine receptors with mutant B subunits acquire sensitivity to A7-selective positive allosteric modulatorss
Stokes, Clare,Garai, Sumanta,Kulkarni, Abhijit R.,Cantwell, Lucas N.,Noviello, Colleen M.,Hibbs, Ryan E.,Horenstein, Nicole A.,Abboud, Khalil A.,Thakur, Ganesh A.,Papke, Roger L.
, p. 252 - 268 (2019)
Homomeric a7 nicotinic acetylcholine receptors (nAChR) have an intrinsically low probability of opening that can be overcome by a7-selective positive allosteric modulators (PAMs), which bind at a site involving the second transmembrane domain (TM2). Mutat
PYRROLE DERIVATIVES AND THEIR METHODS OF USE
-
Page/Page column 59, (2008/06/13)
The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.