1000289-46-2

Upstream product

• 861601-15-2 1-bromo-3-iodo-5-nitrobenzene 
• 827-94-1 2,6-dibromo-4-nitroaniline 
• 6311-60-0 3,5-dibromonitrobenzene 
• 288-13-1 NH-pyrazole 
• 626-40-4 3,5-dibromoaniline 

Downstream Products

• 1000289-47-3 1-benzoyl-3-(3-bromo-5-pyrazol-1-yl-phenyl)thiourea 
• 1438419-63-6 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide 
• 1438424-24-8 3-morpholino-5-(1H-pyrazol-1-yl)aniline 
• 1438424-36-2 3-(1H-pyrazol-1-yl)-5-(pyrimidin-2-yl)aniline 
• 1000289-48-4 (3-bromo-5-pyrazol-1-yl-phenyl)thiourea 

Relevant academic research and scientific papers

MACROCYCLIC RIP2-KINASE INHIBITORS

The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

PYRAZINE KINASE INHIBITORS

Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

ANTIBACTERIAL COMPOSITIONS

Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1 ; Q is hydrogen or cyclopropyl; AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (-O-), thioether (-S-) or amino (-NR)- link, wherein R is hydrogen, -CN or C1-C3 alkyl; X is -C(=O)NR6-, -S(O)NR6-, -C(=O)O- or -S(=O)O- wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or -( C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.