861601-15-2

Usage

Uses

Used in Organic Synthesis:
1-bromo-3-iodo-5-nitrobenzene is used as a reagent and intermediate in the production of various pharmaceuticals, agrochemicals, and dyes. Its unique functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-bromo-3-iodo-5-nitrobenzene is used as a key intermediate for the synthesis of specific drug molecules. Its presence in the molecular structure can influence the pharmacological properties and therapeutic effects of the final drug product.
Used in Agrochemical Industry:
1-bromo-3-iodo-5-nitrobenzene is utilized as a precursor in the development of agrochemicals, such as pesticides and herbicides. Its functional groups contribute to the biological activity and selectivity of these compounds in agricultural applications.
Used in Dye Industry:
In the dye industry, 1-bromo-3-iodo-5-nitrobenzene is employed as a building block for the synthesis of various dyes with specific color properties and applications in textiles, plastics, and other materials.

Upstream product

• 33348-35-5 2-Brom-6-iod-4-nitroanilin 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 88-74-4 2-nitro-aniline 
• 13296-94-1 2-bromo-4-nitroaniline 
• 875-51-4 4-Bromo-2-nitroaniline 
• 180624-08-2 4-bromo-2-nitro-6-iodoaniline 

Downstream Products

• 1000289-32-6 1-benzoyl-3-(3-bromo-5-iodophenyl)thiourea 
• 1000289-33-7 (3-bromo-5-iodophenyl)thiourea 
• 31948-87-5 3-Bromo-5-iodoaniline 

Relevant academic research and scientific papers

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

ANTIBACTERIAL COMPOSITIONS

Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1 ; Q is hydrogen or cyclopropyl; AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (-O-), thioether (-S-) or amino (-NR)- link, wherein R is hydrogen, -CN or C1-C3 alkyl; X is -C(=O)NR6-, -S(O)NR6-, -C(=O)O- or -S(=O)O- wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or -( C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.