89-63-4Relevant articles and documents
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McMaster,Steiner
, p. 547 (1930)
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Fenbendazole production process and production device
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Paragraph 0027; 0035-0037; 0045-0047; 0056-0058; 0076, (2021/01/24)
The invention discloses a fenbendazole production process and a production device, the production process comprises a nitration reaction, a condensation reaction, a reduction reaction and a cyclization reaction, and finally the fenbendazole is obtained through centrifugation and drying. The production device comprises a plurality of reaction kettles, a distillation device and a distillation recovery device, the reaction kettles are respectively a nitration reaction kettle, a condensation reaction kettle, a cyclization reaction kettle and a reduction reaction kettle, and the nitration reactionkettle, the condensation reaction kettle, the cyclization reaction kettle, the distillation device and the reduction reaction kettle are sequentially communicated through feeding pipes. According to the process, the product purity can be improved; few types of chemical reagents are adopted, and methanol and methylbenzene are recycled so that reagent consumption is reduced, waste is avoided, and the process is economical and environmentally friendly; the process route is simple, the production period is shortened, and the production efficiency is improved; according to the production device, automatic feeding is achieved through the feeding mechanism, the automation degree is high, manual operation is reduced, and efficiency is improved.
Amplification of Trichloroisocyanuric Acid (TCCA) Reactivity for Chlorination of Arenes and Heteroarenes via Catalytic Organic Dye Activation
Rogers, David A.,Bensalah, Adam T.,Espinosa, Alvaro Tomas,Hoerr, John L.,Refai, Fares H.,Pitzel, Amy K.,Alvarado, Juan J.,Lamar, Angus A.
supporting information, p. 4229 - 4233 (2019/06/17)
Heteroarenes and arenes that contain electron-withdrawing groups are chlorinated in good to excellent yields (scalable to gram scale) using trichloroisocyanuric acid (TCCA) and catalytic Brilliant Green (BG). Visible-light activation of BG serves to amplify the electrophilic nature of TCCA, providing a mild alternative approach to acid-promoted chlorination of deactivated (hetero)aromatic substrates. The utility of the TCCA/BG system is demonstrated through comparison to other chlorinating reagents and by the chlorination of pharmaceuticals including caffeine, lidocaine, and phenazone.