1000350-06-0

Basic information

• Product Name: 6-(TRIFLUOROMETHYL)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID
• Synonyms: 6-(TRIFLUOROMETHYL)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID;4-Oxo-6-trifluoromethyl-4H-pyran-2-carboxylic acid
• CAS NO: 1000350-06-0
• Molecular Formula: C₇H₃F₃O₄
• Molecular Weight: 208.09
• Mol File: 1000350-06-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(TRIFLUOROMETHYL)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(TRIFLUOROMETHYL)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID(1000350-06-0)
• EPA Substance Registry System: 6-(TRIFLUOROMETHYL)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID(1000350-06-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1000350-06-0(Hazardous Substances Data)

Downstream Products

• 1174756-51-4 3-[3,3,3-trifluoro-2-(phenylhydrazono)propyl]-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 1174756-50-3 5-[3,3,3-trifluoro-2-(phenylhydrazono)propyl]-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 204516-31-4 2-(trifluoromethyl)-4H-pyran-4-one 
• 1363421-70-8 3-[2-(phenylhydrazono)-3,3,3-trifluoropropyl]-1H-pyrazole-5-carboxylic acid 
• 1363421-90-2 (E)-2-(phenylhydrazono)-3-[5-(trifluoromethyl)-1H-pyrazole-3-yl]propanoic acid 
• 1363421-93-5 (Z)-2-(phenylhydrazono)-3-[5-(trifluoromethyl)-1H-pyrazol-3-yl]propanoic acid 
• 1363422-08-5 5-[2-(trifluoromethyl)-1H-indol-3-yl]-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 1363421-52-6 5-[3,3,3-trifluoro-2-(phenylhydrazono)propyl]-1-phenyl-1H-pyrazol-3-carboxylic acid 
• 1363421-82-2 3-[2-(trifluoromethyl)-1H-indol-3-yl]-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 1363421-58-2 1-phenyl-3-[3,3,3-trifluoro-2-(phenylhydrazono)propyl]-1H-pyrazole-5-carboxylic acid 
• 1391763-87-3 6-(trifluoromethyl)-1,4-dihydro-4-oxo-1-(2-hydroxyphenyl)pyridine-2-carboxylic acid 
• 1391764-05-8 2-(trifluoromethyl)-1-(2-hydroxyphenyl)pyridin-4(1H)-one 
• 1391764-04-7 2-(trifluoromethyl)-1-phenylpyridin-4(1H)-one 
• 1391763-85-1 6-(trifluoromethyl)-1,4-dihydro-4-oxo-1-phenylpyridine-2-carboxylic acid 

Relevant articles and documents

First synthesis of 4-oxo-6-trifluoromethyl-4H-thiopyran-2-carboxylic acid and its derivatives

Treatment of 6-trifluoromethylcomanic acid with sodium hydrosulfide afforded for the first time 4-oxo-6-trifluoromethyl-4H-thiopyran-2-carboxylic acid (6-trifluoromethylthiocomanic acid). When heated or treated with H 2SO4, this acid easily underwent decarboxylation leading to 2-trifluoromethyl-4H-thiopyran-4-one. Because of this, both ethyl and methyl 6-tri-fluoromethylthiocomanates were obtained in low yields (15-23%). Decarboxylation of 6-tri-(di)fluoromethylcomanic acids gave 2-tri(di) fluoromethyl-4H-pyran-4-ones in 77-80% yields.