204516-31-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(trifluoromethyl)-4H-pyran-4-one is utilized as a key building block in the development of various pharmaceuticals. Its unique structure allows for the creation of complex organic molecules that can be tailored for specific therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-(trifluoromethyl)-4H-pyran-4-one serves as an essential component in the synthesis of compounds designed to protect crops from pests and diseases, leveraging its structural features to enhance the effectiveness of these products.
Used in Biological Research:
2-(trifluoromethyl)-4H-pyran-4-one is employed as a subject of study in biological research due to its demonstrated anti-inflammatory and antimicrobial properties. This research aims to explore its potential as a therapeutic agent for various conditions and to understand its mechanisms of action.
Used in Organic Chemistry:
As a valuable starting material, 2-(trifluoromethyl)-4H-pyran-4-one is used in organic chemistry for the synthesis of more complex organic molecules. Its trifluoromethyl group and pyran ring provide a versatile platform for chemical modifications and the development of novel compounds with diverse applications.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 1000350-06-0 4-oxo-6-(trifluoromethyl)-4H-pyran-2-carboxylic acid 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 

Downstream Products

• 1363422-02-9 2-(trifluoromethyl)-3-(1-phenyl-1H-pyrazol-5-yl)-1H-indole 
• 1363422-05-2 2-(trifluoromethyl)-3-(1-phenyl-1H-pyrazol-3-yl)-1H-indole 
• 1620579-54-5 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde 
• 1620579-55-6 (3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol 
• 1620578-11-1 (S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620578-12-2 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620578-97-3 (S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 1620579-10-3 (R)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 
• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 

Relevant academic research and scientific papers

ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES

The application relates to 2-imino-hexahydropyrimidin-4-one derivatives of formula (I) which are potent inhibitors of the growth and propagation of the Plasmodium falciparum parasite in human blood and thus useful for the treatment of malaria.

2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer?s disease

PROCESS FOR PREPARING 4-HYDROXYPYRIDINES

A process for preparing 4-hydroxypyridines of formula I, wherein R1, R2, R3 and R4 have the meaning defined in the description.

First synthesis of 4-oxo-6-trifluoromethyl-4H-thiopyran-2-carboxylic acid and its derivatives

Treatment of 6-trifluoromethylcomanic acid with sodium hydrosulfide afforded for the first time 4-oxo-6-trifluoromethyl-4H-thiopyran-2-carboxylic acid (6-trifluoromethylthiocomanic acid). When heated or treated with H 2SO4, this acid easily underwent decarboxylation leading to 2-trifluoromethyl-4H-thiopyran-4-one. Because of this, both ethyl and methyl 6-tri-fluoromethylthiocomanates were obtained in low yields (15-23%). Decarboxylation of 6-tri-(di)fluoromethylcomanic acids gave 2-tri(di) fluoromethyl-4H-pyran-4-ones in 77-80% yields.

New synthetic approaches to 2-perfluoroalkyl-4H-pyran-4-ones

A convenient synthesis of 5-substituted 2-perfluoroalkyl-4H-pyran-4-ones by dehydration of 2,3-dihydro-3-hydroxy-6-perfluoroalkyl-4H-pyran-4-ones is described. The 6-substituted and parent 2-perfluoroalkyl-4H-pyran-4-ones have been more successfully prepared using the condensation of alkyl enol ethers, derived from β-dicarbonyl compounds, with ethyl perfluoroalkanoates.