1000386-58-2

Upstream product

• 948-03-8 1-hydroxy-naphthalene-2-carboxylic acid methyl ester 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 96258-56-9 4-trifluoromethylbenzyl methanesulfonate 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 86-48-6 1-hydroxy-2-naphthoic acid 

Downstream Products

• 1000386-59-3 1-[[4-(trifluoromethyl)phenyl]methoxy]naphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

CFTR-MODULATING ARYLAMIDES

The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

INHIBITORS OF CXCR2

The invention relates to compounds of the formula (I), in which R1, R2, X, A, B and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula (I) and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.