948-03-8

Basic information

• Product Name: METHYL 1-HYDROXY-2-NAPHTHOATE
• Synonyms: 1-hydroxy-2-naphthalenecarboxylicacimethylester;1-Hydroxy-2-naphthalenecarboxylic acid methyl ester;1-hydroxynaphthalene-2-carboxylic acid methyl ester;methyl 1-hydroxynaphthalene-2-carboxylate;2-Naphthalenecarboxylic acid, 1-hydroxy-, Methyl ester;Methyl 1-hydroxy-2-naphthoate 98%;AON METHYL ESTER;METHYL 1-HYDROXY-2-NAPHTHOATE
• CAS NO: 948-03-8
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• EINECS: 213-434-2
• Product Categories: C12 to C63;Carbonyl Compounds;Esters;Aromatic Building Blocks
• Mol File: 948-03-8.mol
• Article Data: 54

Chemical Properties

• Melting Point: 76-80 °C(lit.)
• Boiling Point: 330.5°Cat760mmHg
• Flash Point: 142.5°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 8.59E-05mmHg at 25°C
• Refractive Index: 1.642
• PKA: 8.09±0.50(Predicted)
• CAS DataBase Reference: METHYL 1-HYDROXY-2-NAPHTHOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-HYDROXY-2-NAPHTHOATE(948-03-8)
• EPA Substance Registry System: METHYL 1-HYDROXY-2-NAPHTHOATE(948-03-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 948-03-8(Hazardous Substances Data)

Usage

Uses

Methyl 1-hydroxy-2-naphthoate may be used as a starting reagent for the synthesis of axially chiral benzimidazole derivatives.It may also be employed in the synthesis of the following aza-mollugin derivatives: azamollugin2-desmethyl-azamollugin 2,2-didesmethyl-azamollugin

General Description

The asymmetric unit of the crystal of methyl 1-hydroxy-2-naphthoate contains two independent planar molecules that exhibit intra-molecular hydrogen bonds. Methyl 1-hydroxy-2-naphthoate can be prepared from 1-hydroxy-2-naphthoic acid, via esterification.

InChI:InChI=1/C12H10O3/c1-15-12(14)10-7-6-8-4-2-3-5-9(8)11(10)13/h2-7,13H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 86-48-6 1-hydroxy-2-naphthoic acid 
• 67-56-1 methanol 
• 38077-69-9 1-hydroxy-2-naphthoyl chloride 
• 77-78-1 dimethyl sulfate 
• 1194-57-6 2-thiophthalide 
• 292638-85-8 acrylic acid methyl ester 
• 3709-20-4 dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate 
• 95448-04-7 methyl 1-hydroxy-3,4-dihydronaphthalene-2-carboxylate 
• 60696-09-5 4-hydroxy-2-methoxycarbonyltetralone 
• 703-59-3 homophthalic anhydride 
• 922-67-8 propynoic acid methyl ester 
• 90-15-3 α-naphthol 
• 79-22-1 methyl chloroformate 

Downstream Products

• 345650-95-5 (1-Hydroxy-[2]naphthyl)-diphenyl-methanol 
• 503469-16-7 1-(1-hydroxynaphth-2-yl)-3-(morpholin-4-yl)-propane-1,3-dione 
• 1000922-61-1 1-(2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid methyl ester 
• 1000922-65-5 1-(1-methyl-2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid methyl ester 
• 1354035-55-4 C₁₈H₁₁BrFNO 
• 1569272-99-6 C₁₈H₁₈BrNO₂ 
• 1569273-00-2 C₁₈H₁₈BrNO₂ 
• 1569273-07-9 C₂₀H₁₄FNO 
• 1569273-11-5 C₂₀H₂₁NO₂ 
• 1569273-12-6 C₂₀H₂₁NO₂ 
• 1569273-01-3 C₁₉H₁₂FNO₂ 
• 1569273-04-6 C₁₉H₁₉NO₃ 
• 1569273-05-7 C₁₉H₁₉NO₃ 
• 1414366-63-4 1-{[2-(2-fluorophenyl)-3-oxo-2,3-dihydro-1H-benzo[e]isoindol-5-yl]methyl}-4-pyridin-2-ylpiperidine-4-carbonitrile 

Relevant articles and documents

Structural insight into the anion-water cluster: Stabilised by alcohol and carboxylic acid containing tripodal ligand

A new flexible N-bridged, unsymmetrical, water-soluble tripodal ligand (L) bearing alcohol and carboxylic acid groups has been synthesised and its solid-state interaction with anions has been investigated. The fully deprotonated ligand encapsulates a sodium cation in a half cryptand bowl-shaped cavity (1). The chloride complex 2, contains a cyclohexane-like water cluster incorporating ligand OH groups. However, complexes with bromide and nitrate (3 and 4) are dimeric. Tetrahedral clusters containing two water molecules and two anions were found in complexes 3 and 4. Perchlorate complex 5 forms perchlorate-methanol adducts. Complex 1 forms a hydrophilic cation-water channel and complexes 2-4 form anion-water channels between the hydrophobic layers of the naphthalene moieties. Complexes 2, 5 and 3, 4 are isostructural in nature having similar packing structures.

Fluorescence turn on sensor for sulfate ion in aqueous medium using tripodal-Cu2+ ensemble

We report the selective recognition of sulfate anion in aqueous medium at biological pH 7.2 over the other interfering anions based on naphthoic acid bearing tripodal ligand by applying fluorescence turn off-on mechanism. The carboxylic acid groups in the ligand enhance the solubility in water and enable it to form complex with copper salt. Thus formed L-Cu2+ ensemble quench the fluorescence of the parent ligand and in turn recognize sulfate anion via revival of fluorescence intensity. The 1:2 stoichiometry was confirmed by ESI mass spectral data and Job's plot. The average binding constant was found to be 6.2∈×∈108 M-2. [Figure not available: see fulltext.]

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