10004-45-2 Usage
General Description
3(2H)-Isoxazolone, 5-ethyl-, also known as ethyl isoxazol-3(2H)-one, is a chemical compound with the molecular formula C7H9NO2. It is categorized under the organic compound class known as isoxazolones, which are compounds containing an isoxazole ring fused to a ketone. It is mostly used as an intermediate in the pharmaceutical industry and can be used for organic synthesis. The physical properties of this compound include a heavy atom count of 10, a topological polar surface area of 38.3, and four rotatable bonds. Its stability is influenced by light, heat, and moisture; hence it should be stored in a cool, dry place in a tightly closed container.
Check Digit Verification of cas no
The CAS Registry Mumber 10004-45-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,0 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10004-45:
(7*1)+(6*0)+(5*0)+(4*0)+(3*4)+(2*4)+(1*5)=32
32 % 10 = 2
So 10004-45-2 is a valid CAS Registry Number.
10004-45-2Relevant articles and documents
A novel route to 5-substituted 3-isoxazolols. Cyclization of N,O-diBoc β-keto hydroxamic acids synthesized via acyl Meldrum's acids
Sorensen, Ulrik S.,Falch, Erik,Krogsgaard-Larsen, Povl
, p. 1003 - 1007 (2007/10/03)
3-Isoxazolols are most often synthesized from a β-keto ester and hydroxylamine. This cyclization typically gives rise to a major byproduct, the corresponding 5-isoxazolone. We have found that N,O-diBoc-protected β- keto hydroxamic acids can be synthesized and cyclized to 5-substituted 3- isoxazolols without formation of any byproduct. We present a novel and versatile three-step procedure in which carboxylic acid derivatives are converted into acyl Meldrum's acids which, upon aminolysis with N,O-bis(tert- butoxycarbonyl)hydroxylamine, lead to the N,O-diBoc-protected β-keto hydroxamic acids. These hydroxamic acid analogues were then, upon treatment with hydrochloric acid, cyclized to the corresponding 5-substituted 3- isoxazolols.
