72324-46-0

Usage

Uses

Used in Flavoring Agents:
6-Ethyl-2,2-dimethyl-[1,3]dioxin-4-one is used as a flavoring agent in the food industry due to its unique taste and aroma.
Used in Pharmaceutical Synthesis:
6-Ethyl-2,2-dimethyl-[1,3]dioxin-4-one is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Chemical Compound Synthesis:
6-Ethyl-2,2-dimethyl-[1,3]dioxin-4-one is used as a building block in the synthesis of other chemical compounds, playing a crucial role in the production of various industrial and consumer products.
It is important to handle 6-Ethyl-2,2-dimethyl-[1,3]dioxin-4-one with caution and follow proper safety procedures to prevent any potential risks or hazards.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 66696-76-2 5-(1-hydroxypropylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 33400-61-2 t-Butyl 3-oxopentanoate 
• 67-64-1 acetone 

Downstream Products

• 95395-85-0 N-benzyloxy-3-oxopentanamide 
• 74372-16-0 propionylacetamide 
• 910042-96-5 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one 
• 147122-06-3 C₆₆H₉₀Br₂O₈Si₃ 
• 145020-98-0 6-[(1S,2S,3S)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2,2-dimethyl-[1,3]dioxin-4-one 
• 145020-85-5 6-((1R,2S,3S)-3-Benzyloxy-2-hydroxy-1-methyl-butyl)-2,2-dimethyl-[1,3]dioxin-4-one 
• 145020-84-4 6-((1S,2S,3S)-3-Benzyloxy-2-hydroxy-1-methyl-butyl)-2,2-dimethyl-[1,3]dioxin-4-one 
• 16682-97-6 2-methylacetoacetanilide 
• 52421-75-7 6-ethyl-2-methyl-4(3H)-pyrimidinone 
• 10004-45-2 5-Ethyl-3-hydroxyisoxazol 

Relevant academic research and scientific papers

Ru-catalyzed alkene-alkyne coupling. Total synthesis of amphidinolide P

A coordinatively unsaturated ruthenium complex catalyzed the formation of a carbon-carbon bond between two judiciously chosen alkene and alkyne partners in good yield, and in a chemo- and regioselective fashion, despite the significant degree of unsaturation of the substrates. The resulting 1,4-diene forms the backbone of the cytotoxic marine natural product amphidinolide P. The alkene partner was rapidly assembled from (R)-glycidyl tosylate, which served as a linchpin in a one-flask, sequential three-components coupling process using vinyllithium and a vinyl cyanocuprate. The synthesis of the alkyne partner made use of an unusual anti-selective addition under chelation-control conditions of an allyltin reagent derived from tiglic acid. In addition, a remarkably E-selective E2 process using the azodicarboxylate-triphenylphosphine system is featured. Also featured is the first example of the use of a β-lactone as a thermodynamic spring to effect macrolactonization. The oxetanone ring was thus used as a productive protecting group that increased the overall efficiency of this total synthesis. This work was also an opportunity to further probe the scope of the ruthenium-catalyzed alkene-alkyne coupling, in particular using enynes, and studies using various functionalized substrates are described.

A convenient synthesis of unsymmetrical, substituted γ-pyrones from Meldrum's acid

A unique approach to the synthesis of mono and disubstituted γ-pyrones from acylated Meldrum's acid and vinyl ethers has been developed. The convenient one pot synthesis of these versatile polyketide equivalents is accomplished without strong base or low temperature.