1000578-10-8 Usage
Description
Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is a chemical compound with the molecular formula C11H10N2O3. It is an ester derivative of 4-oxo-3,4-dihydroquinazoline-8-carboxylic acid, a heterocyclic compound. methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate has been studied for its potential pharmaceutical applications and may be utilized in the development of new drugs or as a precursor in organic synthesis. Its structure suggests possible pharmacological activity, although further research is necessary to fully understand its potential effects and applications. Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is of interest to both chemists and pharmacologists as a potential building block in drug development.
Uses
Used in Pharmaceutical Development:
Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is used as a potential pharmaceutical candidate for the development of new drugs due to its unique chemical structure and potential pharmacological activity.
Used in Organic Synthesis:
Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is used as a precursor in organic synthesis, providing a foundation for the creation of more complex molecules with potential applications in various industries.
Used in Drug Development Research:
Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is used as a research tool in drug development, helping chemists and pharmacologists explore its potential effects and applications in the pharmaceutical field.
Used in Chemical Compound Design:
Methyl 4-oxo-3,4-dihydroquinazoline-8-carboxylate is used in the design of chemical compounds, offering a versatile building block for the creation of new molecules with potential applications in various industries, including pharmaceuticals, materials science, and more.
Check Digit Verification of cas no
The CAS Registry Mumber 1000578-10-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,5,7 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1000578-10:
(9*1)+(8*0)+(7*0)+(6*0)+(5*5)+(4*7)+(3*8)+(2*1)+(1*0)=88
88 % 10 = 8
So 1000578-10-8 is a valid CAS Registry Number.
1000578-10-8Relevant articles and documents
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers
Chen, Xiaoling,Clark, Anderson,Crowley, Lindsey,Deselm, Lizbeth,Georgi, Katrin,Goutopoulos, Andreas,Haxell, Thomas,Heasley, Brian H.,Huck, Bayard,Jackson, Jennifer,Johnson, Theresa,Jones, Reinaldo,Lan, Ruoxi,Lin, Jing,Machl, Andreas,Mochalkin, Igor,Moore, Joseph,Neagu, Constantin,Potnick, Justin,Richardson, Thomas E.,Rohdich, Felix,Sherer, Brian,Sutton, Amanda,Tian, Hui,Wilker, Erik,Xiao, Yufang
, p. 14603 - 14619 (2021/10/20)
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase library, 4-benzylamino-quinazoline-8-carboxylic acid amide 1 stood out, with sub-micromolar p70S6k biochemical activity, as the starting point for a structurally enabled p70S6K/Akt dual inhibitor program that led to the discovery of M2698, a dual p70S6k/Akt inhibitor. M2698 is kinase selective, possesses favorable physical, chemical, and DMPK profiles, is orally available and well tolerated, and displayed tumor control in multiple in vivo studies of PAM pathway-driven tumors.