100058-36-4

Usage

Uses

Used in Pharmaceutical Synthesis:
3-p-tolyl-tetrahydrofuran serves as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new compounds with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 3-p-tolyl-tetrahydrofuran is utilized as an intermediate for the production of agrochemicals. Its aromatic and cyclic ether properties make it suitable for the creation of compounds that can be used in crop protection and other agricultural applications.
Used as a Solvent in Organic Reactions:
3-p-tolyl-tetrahydrofuran is employed as a solvent in a range of organic reactions. Its ability to dissolve a variety of substances and facilitate chemical processes makes it a valuable component in laboratory and industrial settings.
Used in the Development of Fine Chemicals:
3-p-tolyl-tetrahydrofuran is also used as a starting material for the development of fine chemicals, which are high-purity chemicals used in various applications, including fragrances, flavors, and specialty chemicals.
Overall, 3-p-tolyl-tetrahydrofuran is a significant compound in the field of organic synthesis, with applications spanning across pharmaceuticals, agrochemicals, solvents for organic reactions, and the development of fine chemicals, highlighting its importance in various industries.

Upstream product

• 1510865-64-1 N'-(dihydrofuran-3(2H)-ylidene)-4-methoxybenzene-sulfonohydrazide 
• 5720-05-8 4-methylphenylboronic acid 
• 1708-29-8 2,5-dihydrofuran 
• 29540-83-8 p-tolyl triflate 

Downstream Products

• 6090-01-3 3-(p-tolyl)-1-butanol 

Relevant academic research and scientific papers

Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer

Alkene hydrocarbofunctionalization represents one of the most important classes of chemical transformations, but related branched-selective examples with unactivated olefins are scarce. Here, we report that catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promote Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, our mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C═C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds.

Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids

The coupling of aromatic moieties with saturated heterocyclic partners is currently an area of significant interest for the pharmaceutical industry. Herein, we present a procedure for the metal-free coupling of 4-, 5-, and 6-membered saturated heterocyclic p-methoxyphenyl (PMP) sulfonylhydrazones with aryl and heteroaromatic boronic acids. This procedure enables a simple, two-step synthesis of a range of functionalized sp2-sp3 linked bicyclic building blocks, including oxetanes, piperidines, and azetidines, from their parent ketones.