1000587-31-4

Upstream product

• 6307-83-1 3-bromo-5-nitro-benzoic acid 

Downstream Products

• 1000587-62-1 5-(1-ethyl-1H-tetrazol-5-yl)-4′-methyl-biphenyl-3-carboxylic acid methyl ester 
• 1000587-63-2 5-(1-ethyl-1H-tetrazol-5-yl)-4′-methyl-biphenyl-3-carboxylic acid 
• 1000587-65-4 4′-methyl-5-(5-trifluoromethyltetrazol-1-yl)biphenyl-3-carboxylic acid methyl ester 
• 1000587-66-5 4′-methyl-5-(5-trifluoromethyltetrazol-1-yl)biphenyl-3-carboxylic acid 
• 1000587-68-7 4′-methyl-5-(5-methyltetrazol-1-yl)biphenyl-3-carboxylic acid methyl ester 
• 1000587-69-8 4′-methyl-5-(5-methyltetrazol-1-yl)-biphenyl-3-carboxylic acid 
• 1258950-64-9 5-[2-(2-bromo-phenyl)-acetylamino]-4'-methyl-biphenyl-3-carboxylic acid methyl ester 
• 1161872-81-6 5-(3-Isopropyl-5-methyl-[1,2,4]triazol-4-yl)-4'-methyl-biphenyl-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Construction of Difluoromethylated Tetrazoles via Silver-Catalyzed Regioselective [3 + 2] Cycloadditions of Aryl Diazonium Salts

A silver-catalyzed regioselective [3 + 2] cycloaddition reaction of PhSO2CF2CHN2 with aryl diazonium salts is described. This protocol enables the straightforward construction of a novel class of difluoromethylated tetrazoles under mild conditions, tolerates a broad spectrum of functionalities, and is applicable to one-pot operation from commercially available aniline derivatives. The synthetic merit of this method is further demonstrated by the facile preparation of versatile difluoromethylated azoles, including a valuable HCF2-analogue of P2X3 receptor antagonist.