100059-65-2Relevant academic research and scientific papers
Towards novel lignin-based aromatic polyesters: In-depth study of the thermal degradation and crystallization of poly(propylene vanillate)
Bikiaris, Dimitrios N.,Chrissafis, Konstantinos,Kourtidou, Dimitra,Papageorgiou, George Z.,Tarani, Evangelia,Terzopoulou, Zoi,Xanthopoulou, Eleftheria,Zamboulis, Alexandra
, (2022/01/15)
The growing environmental concerns over the excessive emissions of greenhouse gasses and the accumulation of synthetic plastics in terrestrial and aqueous recipients have driven the public, academic and industrial awareness towards the production of novel bio-based polymeric materials. Within this frame, poly(propylene vanillate) (PPV) is an alipharomatic engineering polyester with promising thermal and mechanical properties, produced via a two-step melt polycondensation of 4-(3-hydroxypropoxy)-3-methoxybenzoic acid, a monomer derived from the potentially lignin-based vanillic acid. Herein, a systematic investigation of the non-isothermal crystallization, the thermal stability and the decomposition mechanism of PPV was performed, with the implementation of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and pyrolysis-gas chromatography/mass spectroscopy (Py-GC/MS), respectively. The Lauritzen-Hoffman parameters (K and U*) of crystallization were calculated using a combination of the Lauritzen-Hoffman theory and isoconversional methods. The determination of the activation energy, using isoconversional methods, along with the model fitting analysis of mass loss data have led to a first assumption about the thermal degradation profile of the synthesized polyester. Furthermore, decomposition products revealed the two different main degradation mechanisms take place: heterolytic β-hydrogen scission and α-homolytic scission.
ALKYL 4- [4- (5-OXO-2, 3, 5, 11A-TETRAHYD0-5H-PYRR0L0 [2, 1-C] [1, 4] BENZODIAZEPINE-8-YLOXY) -BUTYRYLAMINO]-1H-PYRROLE-2-CARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF A PROLIFERATIVE DISEASE
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Page/Page column 52, (2008/06/13)
A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from -H, -OH, =0, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo, where R and R' are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and RY is H or C1-7 alkyl or H and SOxM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and RE is C1-4 alkyl. The compound is useful for the treatment of proliferative diseases.
Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates
Masterson, Luke A.,Croker, Stephen J.,Jenkins, Terence C.,Howard, Philip W.,Thurston, David E.
, p. 901 - 904 (2007/10/03)
We report examples of a series of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogues 12-15 prepared from a common functionalized building block 11 that can be conveniently synthesized on a large scale and in optically pure form. Isoindoline analogue
Effect of a-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines
Thurston, David E.,Bose, D. Subhas,Howard, Philip W.,Jenkins, Terence C.,Leoni, Alberto,Baraldi, Pier G.,Guiotto, Andrea,Cacciari, Barbara,Kelland, Lloyd R.,Foloppe, Marie-Paule,Rault, Sylvain
, p. 1951 - 1964 (2007/10/03)
Several A-ring-modified analogues of the DNA-binding antitumor agent DC- 81 (5) have been synthesized in order to study structure- reactivity/cytotoxicity relationships. For two molecules (23 and 30) the modifications required the addition of a fourth rin
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4] benzodiazepine and minor-groove-binding oligopyrrole carriers
Baraldi, Pier Giovanni,Balboni, Gianfranco,Cacciari, Barbara,Guiotto, Andrea,Manfredini, Stefano,Romagnoli, Romeo,Spalluto, Giampiero,Thurston, David E.,Howard, Philip W.,Bianchi, Nicoletta,Rutigliano, Cristina,Mischiati, Carlo,Gambari, Roberto
, p. 5131 - 5141 (2007/10/03)
The synthesis, biological activity, and DNA-binding properties of a series of four hybrids prepared by combining polypyrrole minor groove binders and pyrrolo[2,1-c][1,4]benzodiazepine (PBD) 13, related to the naturally occurring anthramycin (3) and DC-81
Design, synthesis and biological activity of a pyrrolo [2, 1- c][1,4]benzodiazepine (PBD)-distamycin hybrid
Baraldi, Pier Giovanni,Cacciari, Barbara,Guiotto, Andrea,Leoni, Alberto,Romagnoli, Romeo,Spalluto, Giampiero,Mongelli, Nicola,Howard, Philip W.,Thurston, David E.,Bianchi, Nicoletta,Gambari, Roberto
, p. 3019 - 3024 (2007/10/03)
We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1- c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybr
