219562-46-6Relevant academic research and scientific papers
Design, synthesis and biological activity of a pyrrolo [2, 1- c][1,4]benzodiazepine (PBD)-distamycin hybrid
Baraldi, Pier Giovanni,Cacciari, Barbara,Guiotto, Andrea,Leoni, Alberto,Romagnoli, Romeo,Spalluto, Giampiero,Mongelli, Nicola,Howard, Philip W.,Thurston, David E.,Bianchi, Nicoletta,Gambari, Roberto
, p. 3019 - 3024 (1998)
We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1- c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybr
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4] benzodiazepine and minor-groove-binding oligopyrrole carriers
Baraldi, Pier Giovanni,Balboni, Gianfranco,Cacciari, Barbara,Guiotto, Andrea,Manfredini, Stefano,Romagnoli, Romeo,Spalluto, Giampiero,Thurston, David E.,Howard, Philip W.,Bianchi, Nicoletta,Rutigliano, Cristina,Mischiati, Carlo,Gambari, Roberto
, p. 5131 - 5141 (2007/10/03)
The synthesis, biological activity, and DNA-binding properties of a series of four hybrids prepared by combining polypyrrole minor groove binders and pyrrolo[2,1-c][1,4]benzodiazepine (PBD) 13, related to the naturally occurring anthramycin (3) and DC-81
Effect of a-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines
Thurston, David E.,Bose, D. Subhas,Howard, Philip W.,Jenkins, Terence C.,Leoni, Alberto,Baraldi, Pier G.,Guiotto, Andrea,Cacciari, Barbara,Kelland, Lloyd R.,Foloppe, Marie-Paule,Rault, Sylvain
, p. 1951 - 1964 (2007/10/03)
Several A-ring-modified analogues of the DNA-binding antitumor agent DC- 81 (5) have been synthesized in order to study structure- reactivity/cytotoxicity relationships. For two molecules (23 and 30) the modifications required the addition of a fourth rin
