1000592-49-3 Usage
Uses
Used in Pharmaceutical Industry:
(R)-Gyramide A is used as a lead compound for the development of new antibiotics, given its potent inhibitory activity against DNA gyrase. This makes it a promising candidate for creating novel treatments to combat bacterial infections, particularly in the context of increasing antibiotic resistance.
Used in Cancer Therapy:
(R)-Gyramide A is used as a potential candidate for cancer therapy due to its cytotoxic effects against various cancer cell lines. Its ability to target and inhibit DNA gyrase, a key enzyme in cancer cell proliferation, positions it as a valuable asset in the fight against cancer.
Used in Drug Discovery and Development:
(R)-Gyramide A is utilized as a starting point for the exploration of new drug candidates, particularly in the fields of anti-cancer and anti-bacterial treatments. Its unique chemical structure and diverse biological activities make it an attractive option for researchers seeking to develop innovative and effective medications.
Check Digit Verification of cas no
The CAS Registry Mumber 1000592-49-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,5,9 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1000592-49:
(9*1)+(8*0)+(7*0)+(6*0)+(5*5)+(4*9)+(3*2)+(2*4)+(1*9)=93
93 % 10 = 3
So 1000592-49-3 is a valid CAS Registry Number.
1000592-49-3Relevant academic research and scientific papers
N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli
Mukherjee, Shubhasish,Robinson, Carolyn A.,Howe, Andrew G.,Mazor, Tali,Wood, Peter A.,Urgaonkar, Sameer,Hebert, Alan M.,RayChaudhuri, Debabrata,Shaw, Jared T.
, p. 6651 - 6655 (2008/09/17)
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.
