1000592-70-0Relevant articles and documents
N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli
Mukherjee, Shubhasish,Robinson, Carolyn A.,Howe, Andrew G.,Mazor, Tali,Wood, Peter A.,Urgaonkar, Sameer,Hebert, Alan M.,RayChaudhuri, Debabrata,Shaw, Jared T.
, p. 6651 - 6655 (2008/09/17)
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.
