100072-86-4

Upstream product

• 64583-16-0 1-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 100072-88-6 C₁₉H₁₉FNO₅P 
• 2729-18-2 1-(4-fluorophenyl)-2-(4-methoxyphenyl)ethan-1-one 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of 1,2-diketones via oxidation of alkynes

The direct oxidation of internal alkynes proceeds efficiently in the presence of CuI as a catalyst to afford the corresponding 1,2-diketones in good yields. This strategy offers a simple and efficient route for the synthesis of 1,2-diketones from an inexpensive copper catalyst and easily available internal alkynes. The advantage of present protocol is further demonstrated by the synthesis of quinoxaline derivatives from alkynes and 1,2-diaminobenzene via one-pot procedure.

Copper-mediated aerobic oxidative cleavage of α,β-unsaturated ketones to 1,2-diketones

The copper-mediated aerobic oxidative cleavage of α,β- unsaturated ketones to synthesize 1,2-diketones by using potassium acetate as a catalyst and sodium iodide as a promoter in acetic acid is described. The protocol has the advantages of using inexpensive and non-toxic raw materials, high yield and simple work-up procedure. the Partner Organisations 2014.

Visible-Light-Induced Photocatalytic Oxidative Decarboxylation of Cinnamic Acids to 1,2-Diketones

A concerted metallophotoredox catalysis has been realized for the efficient decarboxylative functionalization of α,β-unsaturated carboxylic acids with aryl iodides in the presence of perylene bisimide dye to afford 1,2-diketones.

A 1, 2 - dione derivatives of synthetic method (by machine translation)

The invention discloses a synthesis method of 1, 2-dione derivatives by utilizing polyacetylenes. According to the method, in a nitrogen environment, polyacetylenes, an oxidant and an organic solvent are mixed up under the presence of zinc salt as a catalyst, and then heated to react with one another to obtain1, 2-dione derivatives. The substrate of the method is wide in compatibility, mild in condition and high in synthesis yield. The metal zinc salt adopted as the catalyst is low in price and environmentally-friendly. Easily available polyacetylenes are adopted as the substrate of the method, so that the method has the advantages of low cost, high yield, simple operation, readily available raw materials and easy industrial production.

Visible-light-induced C=C bond cleavage of enaminones for the synthesis of 1,2-diketones and quinoxalines in sustainable medium

The C=C double bond cleavage of enaminones has been realized under ambient conditions through visible-light catalysis in the presence of Rose Bengal, which leads to the synthesis of a class of 1,2-diketones without using any metal catalyst. In addition, the one-pot synthesis of quinoxalines has also been achieved under identical photocatalytic conditions by making use of the in situ generated 1,2-diketones as intermediates.

Synthesis of 1,2-diketones from β-keto nitriles via a protection-oxidative-decyanation-deprotection protocol

A variety of 1,2-diketones were prepared from -keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process. Georg Thieme Verlag Stuttgart - New York.

STRUCTURES IN SOLUTION OF ADDUCTS OF 2,8-DIOXA-5-AZA-1-PHOSPHABICYCLOOCTANE AND SUBSTITUTED BENZILS

Adducts of 2,8-dioxa-5-aza-1-phosphabicyclooctane and p,p'-dimethylbenzil, p-methoxy-p'-fluorobenzil, p-fluorobenzil, p,p'-difluorobenzil, p-nitrobenzil and p,p'-dinitrobenzil have been prepared.Although these materials could not be isolated in pure form because of rapid decomposition, the 31P and other NMR spectral data indicate that all of these materials are pentacoordinate in solution.The NMR data also indicate that all of these adducts undergo rapid intramolecular ligand reorganosation at room temperature.Variable temperature NMR measurements indicate that these rearrangements can be slowed and that they all have virtually the same activation energies, ΔG(excit.) 11.4-11.9 kcal/mole.The barrier to ligand reorganization is associated with the 5-membered dioxa containing ring adopting a diequatorial disposition.These results are discussed and compared to other systems.