1000788-71-5

Basic information

• Product Name: 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid
• Synonyms: 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid
• CAS NO: 1000788-71-5
• Molecular Weight: 670.313
• Mol File: 1000788-71-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid(1000788-71-5)
• EPA Substance Registry System: 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid(1000788-71-5)

Safety Data

• Hazardous Substances Data: 1000788-71-5(Hazardous Substances Data)

Upstream product

• 162489-71-6 (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran 
• 1000788-70-4 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 

Downstream Products

• 158966-92-8 montelukast 

Relevant articles and documents

Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium)

The present invention relates to an improved process for the preparation of [R-(E)]-1-[[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic acid, monosodium salt of Formula (I).

PROCESS

A process of preparing montelukast, or a pharmaceutically acceptable salt thereof, which process comprises reacting a protected intermediate of formula (II) as defined in the specification with a cyclopropyl intermediate.