1000788-70-4

Basic information

• Product Name: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate
• Synonyms: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate
• CAS NO: 1000788-70-4
• Molecular Weight: 684.34
• Mol File: 1000788-70-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate(1000788-70-4)
• EPA Substance Registry System: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate(1000788-70-4)

Safety Data

• Hazardous Substances Data: 1000788-70-4(Hazardous Substances Data)

Upstream product

• 869186-47-0 (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran 
• 162489-71-6 (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran 
• 142148-14-9 methyl 1-(acetylthiomethyl)cyclopropylacetic acid 
• 152922-73-1 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester 

Downstream Products

• 1000788-71-5 2-[(1(R)-(3-((E)-2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-3-(2-(1-(tetrahydropyran-2-yloxy)-1-methylethyl)phenyl)propyl)thiomethyl]-2-cyclopropylacetic acid 
• 158966-92-8 montelukast 

Relevant articles and documents

And Menlust sodium process for the preparation of intermediates

The invention relates to a method suitable for preparing montelukast sodium and intermediate 2-(3(S)-(3-(2-(7-chlorine-2-quinolyl) vinyl) phenyl)-3-hydroxypropyl) phenyl)-2-propoxy) tetrahydropyrane (intermediate 3) of the montelukast sodium in a large scale. According to the method, 7-chloroquinaldine and 3-cyanobenzaldehyde are used as starting raw materials, 2-(3-(3-(2-(7-chlorine-2-quinolyl) vinyl) phenyl)-3-oxopropyl) phenyl)-2-propoxy) tetrahydropyrane (intermediate 2) is obtained by six steps of reaction, then intermediate 3 with ee more than 99% and yield more than 90% is obtained by chiral reduction, and the montelukast sodium with high optical purity and high chemical purity is obtained by the intermediate 3 through four steps of reaction.

AN IMPROVED PROCESS FOR THE PREPARATION OF LEUKOTRIENE RECEPTOR ANTAGONIST (MONTELUKAST SODIUM)

The present invention relates to an improved process for the preparation of [R-(E)]-1-[[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic acid, monosodium salt of Formula (I).