100087-43-2Relevant academic research and scientific papers
Base-promoted annulation of amidoximes with alkynes: Simple access to 2,4-disubstituted imidazoles
Hua, Ruimao,Iqbal, Muhammad Asif,Lu, Le,Mehmood, Hina
, (2020)
An efficient construction of imidazole ring by a Cs2CO3-promoied annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synehetic ropte with high atom-utilieation for the synthesis of 2,4-disubstituted imidazoles in good yields under transition-metal-free and ligand-free conditions. Intornal alkynes can also undetgo the annulation to give 2,4,5-trisubstituted imidazoles.
