1000878-46-5

Basic information

• Product Name: C₁₀H₉ClFNO
• Synonyms: C₁₀H₉ClFNO
• CAS NO: 1000878-46-5
• Molecular Weight: 213.639
• Mol File: 1000878-46-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₀H₉ClFNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₉ClFNO(1000878-46-5)
• EPA Substance Registry System: C₁₀H₉ClFNO(1000878-46-5)

Safety Data

• Hazardous Substances Data: 1000878-46-5(Hazardous Substances Data)

Upstream product

• 668-45-1 2-chloro-6-fluorobenzonitrile 
• 676-58-4 methylmagnesium chloride 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.