1000894-49-4

Upstream product

• 38870-89-2 Methoxyacetyl chloride 
• 170017-74-0 1-[1,1-dimethylethoxycarbonyl]-4-(2-aminophenyl)piperazine 
• 88-73-3 2-Chloronitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 170017-73-9 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine 

Downstream Products

• 1001039-79-7 2-methoxy-N-(2-piperazin-1-yl-phenyl)-acetamide 

Relevant academic research and scientific papers

Substituted Piperidines that Increase P53 Activity and the Uses Thereof

In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Aryl piperazine melanocortin MC4 receptor agonists

Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC50=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds