100098-70-2Relevant articles and documents
Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains
Klesiewicz, Karolina,Karczewska, Elzbieta,Nowak, Pawe?,Skiba-Kurek, Iwona,Sito, Edward,Pańczyk, Katarzyna,Koczurkiewicz, Paulina,Zelaszczyk, Dorota,P?kala, Elzbieta,Waszkielewicz, Anna M.,Budak, Alicja,Marona, Henryk,Gunia-Krzyzak, Agnieszka
, p. 543 - 548 (2018/02/19)
In this study, thirty-five N-substituted derivatives of cinnamic acid amide (cinnamamide) were evaluated for anti-Helicobacter pylori activity using an agar disc-diffusion method. Qualitative screening was performed on a reference H. pylori strain (ATCC 43504), resulting in the identification of the three most active compounds, 8 (R,S-(2E)-3-(4-chlorophenyl)-N-(2-hydroxypropyl)prop-2-enamide, minimal inhibitory concentration, MIC = 7.5 μg/mL), 23 ((2E)-3-(4-chlorophenyl)-N-(2-hydroxycyclohexyl)prop-2-enamide, MIC = 10 μg/mL), and 28 ((2E)-3-(4-chlorophenyl)-N-(4-oxocyclohexyl)prop-2-enamide, MIC = 10 μg/mL). These compounds were further tested on twelve well-characterized clinical strains, yielding MIC values that ranged from 10 to 1000 μg/mL. Preliminary safety assessments of the compounds were made using the MTT viability test for cytotoxicity and Ames test for mutagenicity, which showed them to be generally safe, although compounds 8 and 28 showed mutagenic activity at some of the tested concentrations. The results of this study showed the anti-H. pylori potential of cinnamamide derivatives.
Water soluble choline acetyltransferase inhibitors: Sar studies
Mehta,Musso,White
, p. 443 - 446 (2007/10/02)
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