1000994-94-4Relevant articles and documents
Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
Trofymchuk, Serhii,Bugera, Maksym,Klipkov, Anton A.,Ahunovych, Volodymyr,Razhyk, Bohdan,Semenov, Sergey,Boretskyi, Andrii,Tarasenko, Karen,Mykhailiuk, Pavel K.
, p. 12181 - 12198 (2021/09/13)
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
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Paragraph 00197; 00213, (2015/11/09)
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases disorders or symptoms thereof mediated by such metalloenzymes.
COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
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Page/Page column 121; 122, (2014/06/11)
The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a Plasmodium parasite.