1001162-89-5 Usage
Description
2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester, also known as 2-Borono-L-tryptophan 1-Methyl ester, is a chemical compound derived from tryptophan, an essential amino acid. It contains a boronic acid group, which has been shown to have potential biological activities such as antitumor, antiviral, and antibacterial properties. This versatile compound is being studied for its promising therapeutic applications, including cancer therapy and as a fluorescent probe for detecting reactive oxygen species in living cells.
Uses
Used in Cancer Therapy:
2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester is used as an anticancer agent for its potential to target and treat various types of cancer. Its boronic acid group may contribute to its antitumor activity, making it a candidate for further research and development in oncology.
Used as a Fluorescent Probe in Biological Research:
In the field of biological research, 2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester serves as a fluorescent probe for detecting reactive oxygen species in living cells. This application aids scientists in understanding oxidative stress and related cellular processes, which are crucial in many diseases, including cancer and neurodegenerative disorders.
Used in the Synthesis of Anticancer Agents:
2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester is utilized as a key intermediate in the synthesis of novel anticancer agents. Its unique chemical structure allows for the development of new compounds with enhanced efficacy and selectivity in combating cancer.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Borono-1H-indol-1-carboxylic acid 1-Methyl ester is used as a building block for the development of new drugs with potential applications in various therapeutic areas, including oncology, virology, and bacteriology. Its versatility and biological activities make it a valuable compound for drug discovery and design.
Check Digit Verification of cas no
The CAS Registry Mumber 1001162-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,1,6 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1001162-89:
(9*1)+(8*0)+(7*0)+(6*1)+(5*1)+(4*6)+(3*2)+(2*8)+(1*9)=75
75 % 10 = 5
So 1001162-89-5 is a valid CAS Registry Number.
1001162-89-5Relevant articles and documents
A scalable process for the synthesis of the Bcl inhibitor obatoclax
Dairi, Kenza,Yao, Yuxing,Faley, Michael,Tripathy, Sasmita,Rioux, Elise,Billot, Xavier,Rabouin, Daniel,Gonzalez, Gerson,Lavallee, Jean-Francois,Attardo, Giorgio
, p. 1051 - 1054 (2007)
Recently we created the novel indolylprodigiosin derivative 2 (obatodax) and demonstrated its ability to antagonize multiple members of the B-cell lymphoma (Bd) family of antiapoptotic proteins. The compound has shown potent anticancer activity in several animal tumor models. Obatodax is now in Phase 1b and 2 clinical trials directed against multiple hematologic and solid tumor malignancies. To support its clinical development, a new scalable synthesis was required. Obatodax has been prepared using a three-step synthesis, starting from commercially available 4-methoxy-3-pyrrolin-2-one. The reaction sequence involves a haloformylation reaction followed by a Suzuki cross-coupling reaction with an indole-2-boronic add. The synthesis is completed by an acid-mediated condensation with 2,4-dimethyl-1H-pyrrole.
