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2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide, also known as VUF 8430 Dihydrobromide, is a histamine H4 receptor agonist with a high selectivity for histamine H4 over H1 and H3 receptors. It is characterized by its ability to inhibit forskolin-induced, cAMP-mediated increases in β-galactosidase activity and has demonstrated effects in various in vivo models.

100130-32-3

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100130-32-3 Usage

Uses

Used in Pharmaceutical Industry:
2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide is used as a histamine H4 receptor agonist for its potential therapeutic applications in various conditions. It has shown efficacy in enhancing HCl-induced formation of gastric lesions in rats, which may be relevant for the treatment of gastric ulcers or other gastrointestinal disorders. Additionally, it has demonstrated the ability to reduce mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI), suggesting its potential use in managing neuropathic pain.
Used in Research Applications:
In the field of research, 2-(diaminomethylideneamino)ethylsulfanylmethanimidamide dihydrobromide serves as a valuable tool for studying the role of histamine H4 receptors in various physiological and pathological processes. Its high selectivity for histamine H4 receptors makes it an ideal candidate for investigating the specific functions and signaling pathways associated with these receptors, which can contribute to the development of targeted therapies for related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 100130-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,1,3 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100130-32:
(8*1)+(7*0)+(6*0)+(5*1)+(4*3)+(3*0)+(2*3)+(1*2)=33
33 % 10 = 3
So 100130-32-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H

100130-32-3 Well-known Company Product Price

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  • Sigma

  • (V4390)  VUF 8430 dihydrobromide  ≥97% (NMR)

  • 100130-32-3

  • V4390-5MG

  • 833.04CNY

  • Detail
  • Sigma

  • (V4390)  VUF 8430 dihydrobromide  ≥97% (NMR)

  • 100130-32-3

  • V4390-25MG

  • 3,342.69CNY

  • Detail

100130-32-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester S-(2-guanidylethyl)-isothiourea

1.2 Other means of identification

Product number -
Other names 2-Carbamimidamidoethyl carbamimidothioate dihydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100130-32-3 SDS

100130-32-3Upstream product

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