1001346-24-2Relevant academic research and scientific papers
A novel approach to functionalised 5,7,8,9-tetrahydropyrimido[4,5-b][1,4] diazepin-6-ones using intramolecular palladium-catalysed amidation
Carr, Gregory R.,Feron, James L.,Johnson, Paul D.,Roberts, Craig A.,Rudge, David A.,Simpson, Iain,Wrigley, Gail L.
, p. 5049 - 5055 (2012/09/22)
The development of a novel palladium-catalysed amidation approach towards 5,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-6-one templates is highlighted. The route proceeds through the reaction of an amino amide, generated by 1,4-addition of an amine to an
PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
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Page/Page column 56, (2009/05/29)
The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N-(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and Rs
SUBSTITUTED PYRIMIDODIAZEPINES
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Page/Page column 22, (2008/12/08)
The present invention provides PLK1 inhibitor compounds of formula I: Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the t
NOVEL COMPOUNDS
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Page/Page column 120, (2008/06/13)
There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.
