Cas 1001389-38-3,N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide

1001389-38-3

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Basic information

Product Name: N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide
Synonyms:
CAS NO:1001389-38-3
Molecular Formula:
Molecular Weight: 315.199
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide(CAS DataBase Reference)
NIST Chemistry Reference: N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide(1001389-38-3)
EPA Substance Registry System: N-[(2,4-dichlorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide(1001389-38-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1001389-38-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1001389-38-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,3,8 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1001389-38:
(9*1)+(8*0)+(7*0)+(6*1)+(5*3)+(4*8)+(3*9)+(2*3)+(1*8)=103
103 % 10 = 3
So 1001389-38-3 is a valid CAS Registry Number.

1001389-38-3Upstream product

1001389-38-3Downstream Products

1001389-38-3Relevant academic research and scientific papers

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Abdi, Muna H.,Beswick, Paul J.,Billinton, Andy,Chambers, Laura J.,Charlton, Andrew,Collins, Sue D.,Collis, Katharine L.,Dean, David K.,Fonfria, Elena,Gleave, Robert J.,Lejeune, Clarisse L.,Livermore, David G.,Medhurst, Stephen J.,Michel, Anton D.,Moses, Andrew P.,Page, Lee,Patel, Sadhana,Roman, Shilina A.,Senger, Stefan,Slingsby, Brian,Steadman, Jon G.A.,Stevens, Alexander J.,Walter, Daryl S.

experimental part, p. 5080 - 5084 (2010/10/04)

A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X7 receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and compound 31 was identified as a potent P2X7 antagonist with excellent in vivo activity in animal models of pain, and a profile suitable for progression to clinical studies.

Novel Receptor Antagonists and Their Methods of Use

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Page/Page column 34, (2008/06/13)

The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.

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