100141-43-3 Usage
Uses
Used in Pharmaceutical Industry:
CHEMBRDG-BB 7246527 is used as a potential anticancer agent for targeting carbonic anhydrase IX, an enzyme overexpressed in many solid tumors. Its inhibitory activity against this protein suggests its utility in the development of drugs that could treat a range of cancers by inhibiting the growth and progression of tumor cells.
Used in Cancer Research:
In the field of cancer research, CHEMBRDG-BB 7246527 serves as a valuable tool for studying the role of carbonic anhydrase IX in tumor biology. It aids in understanding the mechanisms by which this enzyme contributes to cancer progression and in exploring the therapeutic potential of inhibiting its activity.
Used in Drug Development:
CHEMBRDG-BB 7246527 is utilized in the drug development process as a lead compound for the creation of novel anticancer medications. Its properties as an inhibitor of carbonic anhydrase IX make it a promising candidate for further optimization and refinement to enhance its efficacy, selectivity, and safety profile in clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 100141-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,1,4 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100141-43:
(8*1)+(7*0)+(6*0)+(5*1)+(4*4)+(3*1)+(2*4)+(1*3)=43
43 % 10 = 3
So 100141-43-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H16ClNO/c1-8-6-9(2)12(10(3)7-8)14-11(15)4-5-13/h6-7H,4-5H2,1-3H3,(H,14,15)
100141-43-3Relevant academic research and scientific papers
Modular synthesis of heterocyclic carbene precursors
Paczal, Attila,Benyei, Attila C.,Kotschy, Andras
, p. 5969 - 5979 (2007/10/03)
A series of N-heterocyclic carbene precursors, containing an imidazoline or tetrahydropyrimidine framework, were prepared from ω-chloroalkanoyl chlorides. The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave, depending on the reagents used, either the desired dihydroimidazolium and tetrahydropyrimidinium salts or their parent heterocycles. In this latter case, the second substituent was introduced in an alkylation step. The preparation of carbene precursors bearing chiral or bulky substituents was achieved with comparable efficiency.
