1001411-80-8Relevant articles and documents
Design and synthesis of human immunodeficiency virus entry inhibitors: Sulfonamide as an isostere for the α-ketoamide group
Lu, Rong-Jian,Tucker, John A.,Zinevitch, Tatiana,Kirichenko, Olga,Konoplev, Vitalii,Kuznetsova, Svetlana,Sviridov, Sergey,Pickens, Jason,Tandel, Sagun,Brahmachary, Enugurthi,Yang, Yang,Wang, Jian,Freel, Stephanie,Fisher, Shelly,Sullivan, Alana,Zhou, Jiying,Stanfield-Oakley, Sherry,Greenberg, Michael,Bolognesi, Dani,Bray, Brian,Koszalka, Barney,Jeffs, Peter,Khasanov, Alisher,Ma, You-An,Jeffries, Cynthia,Liu, Changhui,Proskurina, Tatiana,Zhu, Tong,Chucholowski, Alexander,Li, Rongshi,Sexton, Connie
, p. 6535 - 6544 (2007)
The crystal structures of many tertiary α-ketoamides reveal an orthogonal arrangement of the two carbonyl groups. Based on the hypothesis that the α-ketoamide HIV attachment inhibitor BMS 806 (formally BMS378806, 26) might bind to its gp120 target via a s