100158-63-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Pyrrolidin-1-ylmethyl-piperidine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-Pyrrolidin-1-ylmethyl-piperidine is used as a building block to create novel compounds with potential medicinal properties, aiding in drug discovery and the advancement of pharmaceutical formulations.
Used in Drug Discovery:
2-Pyrrolidin-1-ylmethyl-piperidine is employed in drug discovery research to explore its potential as a precursor for compounds that could address unmet medical needs or improve upon existing treatments.
Used in Therapeutic Applications:
While further research is required, 2-Pyrrolidin-1-ylmethyl-piperidine has been studied for its potential therapeutic effects in various medical conditions, indicating its use as a candidate for future medicinal applications once its properties are more fully understood.

InChI:InChI=1/C10H20N2/c1-2-6-11-10(5-1)9-12-7-3-4-8-12/h10-11H,1-9H2

Upstream product

• 4043-87-2 pipecolic Acid 
• 130606-00-7 piperidine-2-carbonyl chloride 
• 130605-98-0 1-(2-piperidinylcarbonyl)pyrrolidine 
• 130497-14-2 (+/-)-[(N-ethoxycarbonyl)piperidine]-2-carboxylic acid 

Downstream Products

• 130497-49-3 2-(4-Hydroxy-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 130497-48-2 2-(4-Cyclohexyl-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 115642-90-5 1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(3-trifluoromethyl-phenyl)-ethanone 
• 130497-45-9 1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-p-tolyl-ethanone 
• 130497-41-5 2-(4-Chloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 130497-42-6 2-(4-Fluoro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 128103-41-3 [3H]-BRL 52537 
• 130497-43-7 2-(4-Nitro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 112282-34-5 1-(4-chlorophenylacetyl)-2-(1-pyrrolidinylmethyl)-piperidine hydrochloride 
• 112282-31-2 1-(3,4-dimethylphenylacetyl)-2-(1-pyrrolidinylmethyl)-piperidine hydrochloride 
• 128103-39-9 1-(4-Bromophenylacetyl)-2-(1-pyrrolidinylmethyl)piperidine maleate 
• 128103-37-7 1-[(3,4-Dichlorophenoxy)acetyl]-2-(1-pyrrolidinylmethyl)piperidine fumarate 
• 130497-39-1 ZT 52656A 
• 130497-44-8 1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(2-trifluoromethyl-phenyl)-ethanone 

Relevant academic research and scientific papers

2-Aminomethyl piperidines as novel urotensin-II receptor antagonists

A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: Novel, highly selective κ opioid analgesics

This paper describes the synthesis and structure-activity relationships as κ opioid analgesics of a novel class of 1-(arylacetyl)-2-(aminomethyl)piperidine derivatives (8). The active conformation of the pharmacophore, with a torsional angle (N1C2C7N8) of 60°, was defined with computational studies and 1H NMR. A quantitative structure-activity relationship study of the arylacetic moiety substitution indicated that the presence of an electron-withdrawing and lipophilic substituent in para and/or meta positions is required for good analgesic activity and κ affinity. The lead compounds (2S)-1-[(3,4-dichlorophenyl)acetyl]-2-(pyrrolidin-1-ylmethyl) piperidine hydrochloride (14) and (2S)-1-[[4-(trifluoromethyl)phenyl]acetyl]-2-(pyrrolidin-1- ylmethyl)piperidine hydrochloride (21) are the most κ/μ selective (respectively 6500:1 and 4100:1) and among the most potent (K(i) κ 0.24 and 0.57 nM, respectively) κ ligands identified so far. In the mouse tail flick model of antinociception, compound 14 (ED50 = 0.05 mg/kg sc) was 25 times more potent than morphine and 16 times more potent than the standard κ ligand U-50488.