100160-69-8 Usage
Description
(1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is a chiral chemical compound with the molecular formula C9H11NO.HCl. It is an amino alcohol, containing both an amine and an alcohol functional group. (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is known for its two enantiomeric forms, (1S,2S) and (1R,2R). Its hydrochloride form enhances its water solubility and stability, making it suitable for a variety of chemical reactions and biological applications. Important in the field of organic chemistry and drug development, (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is valued for its chiral nature and versatile reactivity.
Uses
Used in Pharmaceutical Synthesis:
(1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and functional groups allow for the creation of complex molecules with specific biological activities.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
In the field of asymmetric synthesis, (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride serves as an effective chiral auxiliary. It aids in the selective formation of enantiomerically pure compounds, which is crucial for the development of single-enantiomer drugs with desired therapeutic effects and minimized side effects.
Used in Organic Chemistry Research:
(1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is utilized in organic chemistry research for studying reaction mechanisms and developing new synthetic methodologies. Its reactivity and chiral properties make it a valuable tool for exploring enantioselective reactions and expanding the scope of organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 100160-69-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,1,6 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 100160-69:
(8*1)+(7*0)+(6*0)+(5*1)+(4*6)+(3*0)+(2*6)+(1*9)=58
58 % 10 = 8
So 100160-69-8 is a valid CAS Registry Number.
100160-69-8Relevant articles and documents
Efficient diastereoselective synthesis of cis-2-amino-1-indanol derivatives and cis- and trans-1-amino-2-indanol via Pd-catalyzed hydrogenation
Nguyen, Thi Ha,Ma, Eunsook
supporting information, p. 3717 - 3728 (2021/11/01)
(±)-cis-2-amino-1-indanol was diastereoselectively synthesized from 1,2-indanedion-2-oxime in ethanol at 25 °C under 10% Pd/C-catalyzed hydrogenation conditions. Under the same hydrogenation condition, 1,2-indanedion-2-oxime and their derivatives having one and/or two electron-donating groups in aliphatic or aromatic part of indanyl ring were diastereoselectively reduced to racemic cis-2-amino-1-indanol derivatives. From 1,2-indanedion-1-oxime, (±)-trans-1-amino-2-indanol was obtained in ethanol at 25 °C over a 10% Pd/BaSO4 catalyst. In contrast, the 10% Pd/BaSO4-catalyzed hydrogenation reaction in ethanol at 45 °C afforded cis-1-hydroxyamino-2-indanol from 1,2-indanedion-1-oxime, followed by reduction to form (±)-cis-1-amino-2-indanol. The diastereoselectivity of β-aminoindanols was dependent on the Pd catalyst, reaction temperature, and pH of the reaction medium.
