15028-10-1

Basic information

• Product Name: INDAN-1,2-DIONE-2-OXIME
• Synonyms: SPECS AE-508/36398054;2-OXIMINO-1-INDANONE;INDAN-1,2-DIONE-2-OXIME;1,2-indandione-2-oxime;2-(Hydroxyimino)-2,3-dihydro-1H-inden-1-one;1,2-Indandione-2-oxime 97%
• CAS NO: 15028-10-1
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 15028-10-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 209 °C (dec.)(lit.)
• Boiling Point: 345.9 °C at 760 mmHg
• Flash Point: 163 °C
• Appearance: /solid
• Density: 1.34 g/cm³
• Vapor Pressure: 2.26E-05mmHg at 25°C
• Refractive Index: 1.65
• PKA: 8.96±0.20(Predicted)
• CAS DataBase Reference: INDAN-1,2-DIONE-2-OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: INDAN-1,2-DIONE-2-OXIME(15028-10-1)
• EPA Substance Registry System: INDAN-1,2-DIONE-2-OXIME(15028-10-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 15028-10-1(Hazardous Substances Data)

Usage

General Description

INDAN-1,2-DIONE-2-OXIME, also known as EDDN, is a chemical compound with the molecular formula C9H9NO2. It is used as a reagent for the detection of nitrite ions in environmental samples and in the synthesis of other organic compounds. EDDN is a yellow crystalline solid with a strong odor and is moderately soluble in water. It is a potentially hazardous chemical and should be handled with care due to its toxic and irritant properties. Overall, this chemical compound has applications in various industries, particularly in analytical chemistry and organic synthesis.

InChI:InChI=1/C9H7NO2/c11-9-7-4-2-1-3-6(7)5-8(9)10-12/h1-4,12H,5H2/b10-8+

Upstream product

• 16214-27-0 indan-1,2-dione 
• 110-46-3 isopentyl nitrite 
• 645-45-4 hydrocinnamic acid chloride 
• 7647-01-0 hydrogenchloride 
• 10544-72-6 dinitrogen tetraoxide 
• 83-33-0 inden-1-one 
• 71-43-2 benzene 
• 463-04-7 n-Amyl nitrite 
• 544-16-1 n-Butyl nitrite 

Downstream Products

• 6627-91-4 2-cyanomethylbenzoic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 86-94-2 isoquinoline-1,3-diol 
• 13575-73-0 (±)-cis-2-amino-1-indanol hydrochloride 
• 13575-73-0 (±)-trans-2-amino-1-indanol hydrochloride 
• 4476-30-6 2-carbamoylmethyl-benzoic acid 
• 16214-27-0 indan-1,2-dione 
• 1775-23-1 2-diazo-indan-1-one 
• 89-51-0 Homophthalic acid 
• 19821-21-7 (2-carbethoxyphenyl)acetonitrile 
• 7742-74-7 3-chloroisoquinolin-1(2H)-one 
• 2338-18-3 2-aminoindane hydrochloride 

Relevant articles and documents

A novel one-step conversion of 3,3,3-Triphenylpropionic acid to 10- cyano-10-phenyl-9-anthrone

3,3,3-Triphenylpropionic acid transformed to 10-cyano-10-phenyl-9- anthrone when it was treated in consecutive order with trifluoroacetic anhydride and sodium nitrite in trifluoroacetic acid.

Squaramide-catalysed asymmetric Michael addition/cyclization cascade reaction of 4-arylmethylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones

A highly efficient cinchona alkaloid-derived squaramide catalysed asymmetric Michael/cyclization cascade reaction of 4-arylmethylidene-2,3-dioxopyrrolidines with 2-isothiocyanato-1-indanones was successfully developed. This protocol provides an efficient

Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones

A novel synthesis of 2-(cyanomethyl)benzoic esters from indanone derivatives has been established. This reaction proceeds via a deprotonation of alcohols with a chemical base, followed by a nucleophilic addition to indanones and Beckmann fragmentation. In addition, this reaction could also work under electrochemical conditions, and no external chemical bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcohols.

Preparation method of 2-aminoindan derivative

The invention discloses a preparation method of a 2-aminoindan derivative. The preparation method comprises the following steps: with a 1-indanone derivative as a starting raw material, carrying out oximation reaction, and synchronously reducing carbonyl and hydroxyl oxime under the catalysis of Lewis acid such as aluminum chloride in the presence of a boron metal reducing agent, so as to obtain the 2-aminoindan derivative. The invention further provides the 2-aminoindan derivative prepared by virtue of a synthetic method and a corresponding intermediate derivative. Compared with a synthetic method of the 2-aminoindan derivative in the prior art, the synthetic method disclosed by the invention has the beneficial effects that (1) only two reaction steps are adopted, and the reaction steps are obviously less than the reaction steps in the prior art; (2) the cost is relatively low, the operation is simple and convenient, and the yield is high; and (3) the preparation method is suitable for large-scale industrial production and has relatively good application prospects.