10017-53-5

Usage

Uses

Used in Organic Synthesis:
3'-METHYLPHENOXYACETAMIDE is used as a building block for the synthesis of various organic compounds, contributing to the development of new chemical entities with diverse applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3'-METHYLPHENOXYACETAMIDE is used as a precursor in the development of new drugs and pharmaceuticals. Its structural features and potential biological activities make it a promising candidate for further research and exploration.
However, it is important to note that further research is required to fully understand the properties and potential uses of 3'-METHYLPHENOXYACETAMIDE in the pharmaceutical industry, ensuring its safety and efficacy in drug development.

InChI:InChI=1/C9H11NO2/c1-7-3-2-4-8(5-7)12-6-9(10)11/h2-5H,6H2,1H3,(H2,10,11)

Upstream product

• 108-39-4 3-methyl-phenol 
• 1643-15-8 2-(m-tolyloxy)acetic acid 
• 40926-72-5 2-(m-tolyloxy)acetyl chloride 
• 67386-34-9 2-m-tolyloxy-acetimidic acid ethyl ester; hydrochloride 

Downstream Products

• 1370244-42-0 2-[3-methyl-4-(1-oxo-propyl)phenoxy]ethanethioamide 
• 1370244-07-7 2-[3-methyl-4-(1-oxopropyl)phenoxymethyl]-4-phenylthiazole 
• 1370243-72-3 2-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-phenylthiazole 
• 35370-82-2 2-(m-tolyloxy)ethanethioamide 
• 50635-22-8 3-[(methylphenyl)oxy]acetonitrile 

Relevant academic research and scientific papers

A phenoxy acetyl amine compound preparation method and phenoxy acetamide compounds

The invention belongs to the organic intermediates and the technical field of pharmaceutical intermediates, in particular to a phenoxy acetyl amine compound preparation method and phenoxy acetyl amine compound. The present invention provides a preparation method of the pervasive should be good, and green environmental protection, has better popularization and application value. The results show that the embodiment, the invention provides the above-mentioned method can prepare a plurality of phenoxy acetyl amine compound, and the yield can be 76%.

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

Glutathione S-transferase pi (GSTpi) is a phase II enzyme which protects cells from death and detoxifies chemotherapeutic agents in cancer cells. Ethacrynic acid (EA) is a weak GSTpi inhibitor. Structure modifications were done to improve the ability of EA to inhibit GSTpi activity. Eighteen EA thiazole derivatives were designed and synthesized. Compounds 9a, 9b and 9c with a replacement of carboxyl group of EA by a heterocyclic thiazole exhibited improvement over EA to inhibit GSTpi activity.