10018-19-6 Usage
Uses
Used in Pharmaceutical Industry:
7,8-dihydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolinium chloride is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique chemical structure allows it to be a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 7,8-dihydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolinium chloride serves as a subject of study for understanding its chemical properties, reactivity, and potential interactions with other molecules. This knowledge can be applied to design new chemical processes or develop novel compounds with specific properties.
Used in Quality Control and Analysis:
As an oxidative degradation product of Noscapine, 7,8-dihydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolinium chloride can be used in quality control and analysis of the parent drug. Its presence can be monitored and quantified to ensure the purity and stability of Noscapine in pharmaceutical formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 10018-19-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,1 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10018-19:
(7*1)+(6*0)+(5*0)+(4*1)+(3*8)+(2*1)+(1*9)=46
46 % 10 = 6
So 10018-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H14NO3/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13/h5-6H,3-4,7H2,1-2H3/q+1
10018-19-6Relevant academic research and scientific papers
Metal-Free Activation of C(sp3)–H Bond, and a Practical and Rapid Synthesis of Privileged 1-Substituted 1,2,3,4-Tetrahydroisoquinolines
Choudhury, Santosh Kumar,Rout, Pragati,Parida, Bibhuti Bhusan,Florent, Jean-Claude,Johannes, Ludger,Phaomei, Ganngam,Bertounesque, Emmanuel,Rout, Laxmidhar
, p. 5275 - 5292 (2017/09/29)
The reaction of cotarnine and acyl/aryl ketones in “green” solvents provides an efficient approach to an array of privileged 1,2,3,4-tetrahydroisoquinolines in excellent yields by metal-free activation of C(sp3)–H bonds. This one-pot procedure takes place under base-free conditions at room temperature, and tolerates a wide range of functionalities. The reaction is highly chemoselective, can be performed on a multi-gram scale, and pure products are isolated by simple filtration without workup. Interestingly, the complementary two-step procedure from cotarnine halide salts gives the Mannich products in good yields. The scope was elaborated to 9-bromocotarnine salts to access a range of 9-bromonoscapine-derived analogues. The methodology has been developed considering the structural similarity of cotarnine derivatives to noscapinoids, which represent an emerging class of microtubule-modulating anticancer agents.
