100184-22-3Relevant academic research and scientific papers
I2-Catalyzed transformation of: O -aminobenzamide to o -ureidobenzonitrile using isothiocyanates
Chaithra, Nagaraju,Gurukiran, Mahesha,Lokanath, N. K.,Mamatha, Mahesha,Mantelingu, Kempegowda,Rangappa, Kanchugarakoppal S.,Shamanth, Sadashivamurthy
supporting information, p. 2678 - 2684 (2020/04/17)
The present work describes an unexpected and unique protocol for the iodine catalysed synthesis of o-ureidobenzonitriles using o-aminobenzamides and isothiocyanates via intramolecular rearrangement. The metal-free route achieved here is insensitive to moisture and applicable to the synthesis of a wide variety of o-ureidobenzonitriles with excellent yields even in a scalable fashion.
