607-28-3

Basic information

• Product Name: ISATIN-3-OXIME
• Synonyms: 2,3-INDOLINEDIONE 3-OXIME;INDOLE-2,3-DIONE OXIME;ISATIN-BETA-OXIME;ISATIN-3-OXIME;BETA-ISATOXIME;3-oximeindole-2,3-dione;indole-2,3-dione,3-oxime;3-hydroxyiminoindolin-2-one
• CAS NO: 607-28-3
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• EINECS: 210-132-2
• Product Categories: Indoles;Simple Indoles
• Mol File: 607-28-3.mol
• Article Data: 27

Chemical Properties

• Melting Point: 228°C (dec.)
• Boiling Point: 400.5 °C at 760 mmHg
• Flash Point: 196 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 4.43E-08mmHg at 25°C
• Refractive Index: 1.706
• PKA: 9.19±0.20(Predicted)
• BRN: 136198
• CAS DataBase Reference: ISATIN-3-OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: ISATIN-3-OXIME(607-28-3)
• EPA Substance Registry System: ISATIN-3-OXIME(607-28-3)

Safety Data

• Safety Statements: 22-24/25
• RTECS: NL7980000
• HazardClass: IRRITANT
• Hazardous Substances Data: 607-28-3(Hazardous Substances Data)

Usage

General Description

ISATIN-3-OXIME is a chemical compound known for its versatile biological activities. It's an oxime derivative of the indole compound Isatin, a strong and versatile pharmacophore that can form the basis for a wide range of biologically active compounds. It is often used as a synthon in organic chemistry due to its ease of modification. In terms of medical and pharmaceutical applications, ISATIN-3-OXIME, like other Isatin derivatives, has shown potential anti-bacterial, anti-cancer, anti-convulsant and anti-viral activities. However, further studies are required to fully uncover its potential therapeutic applications.

InChI:InChI=1/C8H6N2O2/c11-8-7(10-12)5-3-1-2-4-6(5)9-8/h1-4,12H,(H,9,10,11)

Upstream product

• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 75-52-5 nitromethane 
• 91-56-5 indole-2,3-dione 
• 59-48-3 2-oxoindole 
• 62-53-3 aniline 
• 7803-49-8 hydroxylamine 
• 14003-18-0 ethyl 2-(2-oxoindolin-3-ylidene)cyanoacetate 
• 762241-88-3 2,3-indoledione-3-oxime O-acetate 
• 880771-82-4 2,3-indoledione 3-oxime O-benzoate 
• 64-17-5 ethanol 
• 110-91-8 morpholine 
• 880771-84-6 2,3-indoledione 3-oxime O-(2-nitrobenzene)sulfonate 
• 110-89-4 piperidine 
• 102721-78-8 1-(N-arylamino)-1-methylthio-2-nitroethane 

Downstream Products

• 117069-75-7 3-aminoindolin-2-one 
• 36185-83-8 N'-(2-cyanophenyl)-N,N-dimethylimidoformamide 
• 34923-95-0 4-(phenylamino)quinazoline 
• 457932-97-7 N-(3-chloro-4-fluorophenyl)quinazolin-4-amine 
• 34923-98-3 4-(p-hydroxyphenyl)aminoquinazoline 
• 607-68-1 2,4-dichloroquinazoline 

Relevant articles and documents

Molecular modeling and in vitro studies of a neutral oxime as a potential reactivator for acetylcholinesterase inhibited by paraoxon

The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited by the pesticide paraoxon (AChE/POX) as well as a novel potential scaffold for further synthetic modifications. The multicriteria decision methods (MCDM) allowed the identification of the best docking poses of those molecules inside AChE/POX for further molecular dynamic (MD) studies, while Ellman’s modified method enabled in vitro inhibition and reactivation assays. In corroboration with the theoretical studies, our experimental results showed that isatin-O have a reactivation potential capable of overcoming 2-PAM at the initial moments of the assay. Despite not achieving better results than obidoxime, this molecule is promising for being an active neutral oxime with capacity of crossing the blood–brain barrier (BBB), to reactivate AChE/POX inside the central and peripheral nervous systems. Moreover, the fact that isatin-O can also act as anticonvulsant makes this molecule a possible multipotent reactivator. Besides, the MCDM method showed to be an accurate method for the selection of the best docking poses generated in the docking studies.

The benzonitrile derivative

[A] suppressing the generation of impurities caused by side reactions and reaction, and benzonitrile derivative can be obtained in high purity of the benzonitrile derivative method. The compound represented by general formula [a] I, III and IV compound represented by general formula compound represented by a general formula selected from the group consisting of tertiary amines in the presence of at least 1 species is reacted, the benzonitrile derivative represented by general formula II comprises obtaining the benzonitrile derivative. In the general formula I, R1 - R4 Each independently, a hydrogen atom, an alkyl group of carbon number 1 - 5 represent the like, in the general formula II, R21 - R24 Each independently, a hydrogen atom, an alkyl group of carbon number 1 - 5 represent the like, in the general formula III, R31 - R33 Is, each independently represents an alkyl group or a phenyl group, having the general formula IV in, R41 - R44 Is, each independently represents an alkyl group. The details of the code as described herein. [Drawing] no

1,3-Dipolar Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and O-Vinylphosphonylated Salicylaldehydes for Diastereoselective Synthesis of Oxindole Spiro-P, N-polycyclic Heterocycles

An efficient stereoselective assembly strategy for the construction of pyrrolidin-2,3′-oxindole cis-fused phosphadihydrocoumarins was established. The process involves the condensation of O-vinylphosphonylated salicylaldehydes and 3-amino oxindoles followed by intermolecular cycloaddition with high diastereoselectivity and atom economy.