1002104-13-3Relevant academic research and scientific papers
Reaction of hydrazide of (Tetrazol-5-YL)acetic acid with isothiocyanates and antimicrobial investigations of newly-obtained compounds
Wujec, Monika,Kosikowska, Urszula,Paneth, Piotr,Malm, Anna
, p. 2617 - 2626 (2008/09/18)
In the reaction of hydrazide of (tetrazol-5-yl)acetic acid (1) with isothiocyanate the respective thiosemicarbazide derivatives 2 were obtained. Further cyclization with 2% NaOH led to the formation of 3-[(tetrazol-5-yl)- methyl]-4-substituted-l,2,4-triazoline-5-thione 3. The structures of all new products were confirmed by analytical and spectroscopic methods. Five compounds were screened for their in vitro activity against some species of aerobic bacteria and fungi. Derivatives of 1,2,4-triazoline-5-thione can exist in two major tautomeric forms; thiole and thione. We have established experimentally that all obtained compounds 3, were in the thione form. Geometry optimization oftautomeric forms of 3c and 3f was carried out.
