1002104-07-5

Basic information

• Product Name: Tetrazole-5-acetohydrazide
• Synonyms: Tetrazole-5-acetohydrazide
• CAS NO: 1002104-07-5
• Molecular Formula: C₃H₆N₆O
• Molecular Weight: 142.11934
• Mol File: 1002104-07-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tetrazole-5-acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrazole-5-acetohydrazide(1002104-07-5)
• EPA Substance Registry System: Tetrazole-5-acetohydrazide(1002104-07-5)

Safety Data

• Hazardous Substances Data: 1002104-07-5(Hazardous Substances Data)

Usage

General Description

Tetrazole-5-acetohydrazide is a chemical compound with the molecular formula C4H6N6O. It is a derivative of tetrazole and acetohydrazide and is often used as a building block in the synthesis of pharmaceuticals and agricultural chemicals. Tetrazole-5-acetohydrazide has potential applications as an antiviral and antibacterial agent, and has also been studied for use in the development of new materials. Its unique chemical structure makes it a versatile intermediate in organic synthesis, and its properties make it a valuable compound in the field of medicinal and agrochemical research.

Upstream product

• 13616-37-0 ethyl (tetrazol-5-yl)acetate 

Downstream Products

• 1002104-13-3 4-benzyl-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 
• 1002104-12-2 4-(2-fluorophenyl)-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 
• 1002104-08-6 4-phenyl-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 
• 1002104-10-0 4-(4-methoxyphenyl)-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 
• 1002104-09-7 4-(4-tolyl)-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 
• 1002104-11-1 4-(4-bromophenyl)-1-[(tetrazol-5-yl)acetyl]thiosemicarbazide 

Relevant articles and documents

Tetrazolylhydrazides as selective fragment-like inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A

The JumonjiC-domain-containing histone demethylase 2A (JMJD2A, KDM4A) is a key player in the epigenetic regulation of gene expression. Previous publications have shown that both elevated and lowered enzyme levels are associated with certain types of cancer, and therefore the definite role of KDM4A in oncogenesis remains elusive. To identify a novel molecular starting point with favorable physicochemical properties for the investigation of the physiological role of KDM4A, we screened a number of molecules bearing an iron-chelating moiety by using two independent assays. In this way, we were able to identify 2-(1H-tetrazol-5-yl)acetohydrazide as a novel fragment-like lead structure with low relative molecular mass (Mr=142 Da), low complexity, and an IC50 value of 46.6 μm in a formaldehyde dehydrogenase (FDH)-coupled assay and 2.4 μm in an antibody-based assay. Despite its small size, relative selectivity against two other demethylases could be demonstrated for this compound. This is the first example of a tetrazole group as a warhead in JMJD demethylases. Anchor fragment: To develop non-promiscuous metalloenzyme inhibitors, a metal-complexing acetohydrazide group was integrated in a tetrazolyl fragment, which can be matured into a scaffold to promote further selectivity at the ligand backbone binding site of these emerging drug targets.