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1002113-03-2

6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1002113-03-2 Structure

  • Basic information

    1. Product Name: 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone
    2. Synonyms: 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone
    3. CAS NO:1002113-03-2
    4. Molecular Formula:
    5. Molecular Weight: 295.295
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1002113-03-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone(1002113-03-2)
    11. EPA Substance Registry System: 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone(1002113-03-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1002113-03-2(Hazardous Substances Data)

1002113-03-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1002113-03-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,2,1,1 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1002113-03:
(9*1)+(8*0)+(7*0)+(6*2)+(5*1)+(4*1)+(3*3)+(2*0)+(1*3)=42
42 % 10 = 2
So 1002113-03-2 is a valid CAS Registry Number.

1002113-03-2Relevant articles and documents

New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5- or 6-(3-aryl- 2-propenoyl)-2(3H)-benzoxazolones

Ivanova, Yordanka B.,Momekov, Georgi T.,Petrov, Ognyan I.

, p. 23 - 28 (2013)

A number of chalcones bearing an oxazole cycle were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3 H )-benzoxazolone or 6-acetyl-2(3 H )-benzoxazolone and the appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines - BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration- dependent cytotoxic effects at micromolar concentrations. Exposure of the BV-173 tumor cell line to compound 3f results in strong monoand oligonucleosomal fragmentation of genomic DNA, as evidenced by a 'cell death detection' ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound.

Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones

Ivanova,Momekov,Petrov,Karaivanova,Kalcheva

, p. 1382 - 1387 (2008/09/17)

A series of 12 new Mannich bases with chalcone core structure were synthesized as potential antineoplastic agents, via N-aminomethylation of two parent 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. The newly synthesized compounds as well as the chalcone prototypes were evaluated for cytotoxicity in the human pre-B-cell leukemia cell line BV-173 using the MTT-dye reduction assay. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations. Ten of the Mannich bases characterized by significant activity in BV-173 were further evaluated against the chronic myeloid leukemia cell line K-562 and were found to suppress the growth of these cells at relatively higher concentrations as compared to the former tumor model. Selected Mannich bases induced programmed cell death in BV-173 at a concentration of 2.5 μM as evidenced by the encountered DNA-laddering. Taken together our data suggest that the presented heterocyclic chalcone derived Mannich bases necessitate detailed pharmacological evaluation in order to define further the structure activity relationships, in a larger spectrum of tumor models and to elucidate the mechanisms implicated in the observed cytotoxic effects.

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