1002129-40-9

Basic information

• Product Name: C₂₁H₁₇F₃O₄
• CAS NO: 1002129-40-9
• Molecular Weight: 390.359
• Mol File: 1002129-40-9.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₇F₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₇F₃O₄(1002129-40-9)
• EPA Substance Registry System: C₂₁H₁₇F₃O₄(1002129-40-9)

Safety Data

• Hazardous Substances Data: 1002129-40-9(Hazardous Substances Data)

Upstream product

• 1369534-94-0 2-(4-bromophenoxy)-1,3-diacetoxypropane 
• 1369534-95-1 2-(4-bromophenoxy)-3-tosyloxy-1-propanol 
• 1369534-96-2 3-(4-bromophenoxy)oxetane 
• 1369534-97-3 ethyl (2E,4E)-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-5-(4-trifluoromethylphenyl)-2,4-pentadienoate 
• 1369534-98-4 ethyl (2E,4Z)-5-[4-(oxetan-3-yloxy)phenyl]-5-(4-trifluoromethylphenyl)-2,4-pentadienoate 
• 1002127-25-4 ethyl (2E,4Z)-5-bromo-5-(4-trifluoromethylphenyl)-2,4-pentadienoate 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 1002126-70-6 (2E,4Z)-N-(3-hydroxy-2-oxo-1,2,3,4-tetrahydro-5-quinolyl)-5-[4-(oxetan-3-yloxy)phenyl]-5-(4-trifluoromethylphenyl)-2,4-pentadienamide 

Relevant articles and documents

Discovery of novel 5,5-diarylpentadienamides as orally available transient receptor potential vanilloid 1 (TRPV1) antagonists

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the phenyl ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b, which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mechanical allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.