100217-74-1

Usage

InChI:InChI=1/C23H28N4O7/c24-10-15(28)9-17-22(32)27-18(23(33)34)8-14-6-12(2-4-20(14)30)11-1-3-19(29)13(5-11)7-16(25)21(31)26-17/h1-6,15-18,28-30H,7-10,24-25H2,(H,26,31)(H,27,32)(H,33,34)/t15-,16+,17+,18+/m1/s1

Upstream product

• 1313436-87-1 C₃₃H₃₈N₄O₉ 
• 134038-81-6 3'-<(Z)-2-(tert-Butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-4,4'-dibenzyloxy-3-(1,3-dioxan-2-yl)biphenyl 
• 134038-81-6 (Z)-3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-acrylic acid methyl ester 
• 145240-76-2 2(S)-benzyloxycarbonylamino-3-{4,4'-bisbenzyloxy-3'-[2(S)-benzyloxycarbonyl-2-(5-benzyloxycarbonylamino-2(S)-tert-butoxycarbonylamino-4(R)-hydroxypentanoylamino)ethyl]biphenyl-3-yl}propionic acid 
• 145240-78-4 3-<(S)-2-(tert-Butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxy-3'-(1,3-dioxan-2-yl)biphenyl 
• 134038-82-7 3-<(S)-2-(tert-Butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxybiphenyl-3'-carbaldehyde 
• 145240-75-1 3'-<(Z)-2-(tert-Butoxycarbonylamino)-2-carboxyvinyl>-4,4'-dibenzyloxy-3-(1,3-dioxan-2-yl)biphenyl 
• 145240-77-3 3-<(S)-2-(tert-Butoxycarbonylamino)-2-carboxyethyl>-4,4'-dibenzyloxy-3'-(1,3-dioxan-2-yl)biphenyl 
• 134038-79-2 4,4'-Dibenzyloxy-3-(1,3-dioxane-2-yl)-3'-(1,3-dithiane-2-yl)biphenyl 
• 134038-80-5 4,4'-Dibenzyloxy-3-(1,3-dioxane-2-yl)biphenyl-3'-carbaldehyde 
• 135582-94-4 (R)-3-benzyloxycarbonyl-5-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)ethyl>-2,2-dimethyl-1,3-oxazolidine 
• 135638-41-4 (R)-3-benzyloxycarbonyl-5-<(Z)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-2,2-dimethyl-1,3-oxazolidine 
• 134038-76-9 (R)-3-Benzyloxycarbonyl-5-<(S)-N-tert-butoxycarbonylalanin-3-yl>-2,2-dimethyl-1,3-oxazolidine 
• 134038-78-1 2-(2-Benzyloxy-5-iodophenyl)-1,3-dithian 

Relevant academic research and scientific papers

Flexible total synthesis of biphenomycin B

A total synthesis of the biaryl antibiotic biphenomycin B is reported which makes use of three independent building blocks (key steps were a clean Suzuki-Miyaura coupling of a free acid iodide, a novel 4-hydroxyornithine synthesis, and a high-yielding macrolactamization); a practical deprotection protocol allowed isolation of the target compound with excellent recovery and purity. The Royal Society of Chemistry.

The Synthesis of Biphenomycin B

Biphenomycin B, a highly potent antibiotic against Gram-negative, β-lactam-resistant bacteria, which was previously isolated from culture filtrates of Streptomyces griseorubiginosus No. 43708, has now been synthesized.