145240-75-1

Upstream product

• 134038-81-6 (Z)-3-(4,4'-Bis-benzyloxy-3'-[1,3]dioxan-2-yl-biphenyl-3-yl)-2-tert-butoxycarbonylamino-acrylic acid methyl ester 
• 1761-61-1 5-bromosalicyclaldehyde 
• 121124-94-5 2-benzyloxy-5-bromobenzaldehyde 
• 1761-62-2 5-iodosalicyclaldehyde 
• 134038-81-6 3'-<(Z)-2-(tert-Butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-4,4'-dibenzyloxy-3-(1,3-dioxan-2-yl)biphenyl 
• 100-44-7 benzyl chloride 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 134038-79-2 4,4'-Dibenzyloxy-3-(1,3-dioxane-2-yl)-3'-(1,3-dithiane-2-yl)biphenyl 
• 134038-80-5 4,4'-Dibenzyloxy-3-(1,3-dioxane-2-yl)biphenyl-3'-carbaldehyde 
• 134038-78-1 2-(2-Benzyloxy-5-iodophenyl)-1,3-dithian 
• 121124-96-7 2-(2-(benzyloxy)-5-bromophenyl)-1,3-dioxane 
• 134038-89-4 2-benzyloxy-5-iodobenzaldehyde 

Downstream Products

• 134038-86-1 benzyl 2(S)-(5-benzyloxycarbonylamino-2(S)-tert-butoxycarbonylamino-4(R)-hydroxypentanoylamino)-3-[4,4'-bisbenzyloxy-3'-(2(S)-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonylethyl)biphenyl-3-yl]propionate 
• 134038-82-7 3-<(S)-2-(tert-Butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxybiphenyl-3'-carbaldehyde 
• 145240-78-4 3-<(S)-2-(tert-Butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxy-3'-(1,3-dioxan-2-yl)biphenyl 
• 134038-87-2 benzyl 5,17-bisbenzyloxy-14(S)-benzyloxycarbonylamino-11(S)-(3-benzyloxycarbonylamino-2(R)-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]-henicosa-1(19),2,4,6(21),16(20),17-hexaene-8(S)-carboxylate 
• 145240-76-2 2(S)-benzyloxycarbonylamino-3-{4,4'-bisbenzyloxy-3'-[2(S)-benzyloxycarbonyl-2-(5-benzyloxycarbonylamino-2(S)-tert-butoxycarbonylamino-4(R)-hydroxypentanoylamino)ethyl]biphenyl-3-yl}propionic acid 
• 134038-83-8 (S)-3-[3'-((S)-2-Amino-2-benzyloxycarbonyl-ethyl)-4,4'-bis-benzyloxy-biphenyl-3-yl]-2-benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester 
• 121125-08-4 (E)-2-Benzyloxycarbonylamino-3-[4,4'-bis-benzyloxy-3'-((S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-biphenyl-3-yl]-acrylic acid 2-trimethylsilanyl-ethyl ester 
• 121125-11-9 3-<(S)-2-Benzyloxycarbonylamino-2-(trimethylsilylethoxycarbonyl)ethyl>-3'-<(S)-2-tert-butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxybiphenyl 
• 134038-84-9 C₇₃H₈₄N₄O₁₄Si 
• 134038-85-0 (S)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester 
• 100217-74-1 biphenomycin B 

Relevant academic research and scientific papers

Total synthesis of the biphenomycins; III. Synthesis of biphenomycin B

The total synthesis of the cyclopeptide biphenomycin B (1b), a compound exhibiting a potent antibacterial activity against Gram-positive bacteria, is described. The non-proteinogenic amino acid (S,S)-diisotyrosine (2) was prepared by enantioselective hydrogenation of the corresponding didehydroamino acids. The 15-membered ansa ring was obtained in 85% yield within 5 minutes by ring closure of the appropriate linear pentafluorophenyl ester in the two phase system chloroform-aqueous sodium hydrogen carbonate without dilution.

The Synthesis of Biphenomycin B

Biphenomycin B, a highly potent antibiotic against Gram-negative, β-lactam-resistant bacteria, which was previously isolated from culture filtrates of Streptomyces griseorubiginosus No. 43708, has now been synthesized.