1002234-62-9Relevant academic research and scientific papers
Expedient synthesis of 6-aryl derivatives of 3,4-dihydro-1,4,4a,6a- tetraaza-benzo[a]fluoren-2-one: A new heterocyclic framework
Reddy, Gade Srinivas,Rajasekhar, Kadaboina,Praveen, Cherukupally,Mukkanti, Kaga,Reddy, Padi Pratap
, p. 3884 - 3893 (2008)
3,4-Dihydro-1,4,4a,6a-tetraaza-benzo[a]fluoren-2-one, a new tetracyclic heterocyclic framework, is designed through a simple and convenient synthetic sequence. Its 6-aryl derivatives are synthesized starting from 1H-indole-2-carboxylic acid. The reaction of differently substituted phenacyl bromides with 1H-indole-2-carboxylic acid and POCl3-mediated cyclization of the resultant 1H-indole-2-carboxylic acid phenacyl ester provided 2-oxa-4a-aza-fluoren-1-one, and its sequential reaction with hydrazine and 2-chloro-acetamide furnished the desired new heterocyclic compounds 7a-f. Copyright Taylor & Francis Group, LLC.
