100229-84-3Relevant academic research and scientific papers
Integrated chemical process. Construction of highly substituted allylic moieties from allylic sulfones in one-pot
Orita, Akihiro,Watanabe, Akihiro,Tsuchiya, Hiroshi,Otera, Junzo
, p. 2889 - 2898 (2007/10/03)
According to 'integrated chemical process', a novel one-pot process for construction of highly substituted allylic moieties has been achieved. A series of alkylation of allylic sulfones and palladium-catalyzed reductive desulfonylation by use of LiBHEt3 is integrated. The double alkylation furnishes more substituted olefins. Use of arylzinc compounds in place of the hydride enables electrophilic alkylation/nucleophilic arylation in one-pot. The integrated process provides higher overall yields than the corresponding stepwise process.
