49639-05-6

Basic information

• Product Name: Benzene, [(2-methyl-2-propenyl)sulfonyl]-
• Synonyms: HMS1546A01
• CAS NO: 49639-05-6
• Molecular Formula: C10H12O2S
• Molecular Weight: 196.27
• Mol File: 49639-05-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 42-43 °C
• Boiling Point: 120-121 °C(Press: 1 Torr)
• Density: 1.1621 g/cm3
• CAS DataBase Reference: Benzene, [(2-methyl-2-propenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(2-methyl-2-propenyl)sulfonyl]-(49639-05-6)
• EPA Substance Registry System: Benzene, [(2-methyl-2-propenyl)sulfonyl]-(49639-05-6)

Safety Data

• Hazardous Substances Data: 49639-05-6(Hazardous Substances Data)

Upstream product

• 219618-19-6 1,2-bis-benzenesulfonyl-2-methyl-propane 
• 4972-29-6 benzenesulphinyl chloride 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 873-55-2 sodium benzenesulfonate 
• 618-41-7 Benzenesulfinic acid 
• 100-58-3 phenylmagnesium bromide 
• 43161-07-5 ((2-methylallyl)sulfinyl)benzene 
• 177750-79-7 N-benzyloxy-1-(phenylsulfonyl)methanimine 
• 98-09-9 benzenesulfonyl chloride 
• 182123-92-8 1,1,1,3,3,3-hexamethyl-2-(2-methylallyl)-2-(trimethylsilyl)trisilane 
• 38131-57-6 2-benzenesulfonylmethacrylic acid methyl ester 
• 588-63-6 3-phenoxypropyl bromide 
• 24892-63-5 1-allyloxy-2-iodobenzene 
• 768-93-4 1-iodoadamantane 

Downstream Products

• 115961-92-7 (1R,3S)-3-Benzenesulfonyl-4-methyl-1-phenyl-pent-4-en-1-ol 
• 115961-92-7 (1S,3S)-3-Benzenesulfonyl-4-methyl-1-phenyl-pent-4-en-1-ol 
• 142076-24-2 ((3S,4R)-2,4-Dimethyl-5-nitro-pent-1-ene-3-sulfonyl)-benzene 
• 142076-24-2 ((3S,4S)-2,4-Dimethyl-5-nitro-pent-1-ene-3-sulfonyl)-benzene 
• 72592-56-4 2-methyl-3-(phenylsulfonyl)-1-heptene 
• 100229-84-3 (2-Methyl-non-1-ene-3-sulfonyl)-benzene 
• 1575-67-3 2-(2-methyl-allyl)-malonic acid diethyl ester 
• 105-53-3 diethyl malonate 
• 54897-35-7 2-methyl-1-phenylsulfonyl-1-propene 
• 75593-22-5 2-methyl-4-phenyl-3-(phenylsulfonyl)-1-butene 
• 142076-19-5 1-((Z)-4-Benzenesulfonyl-3-methyl-1-nitromethyl-but-3-enyl)-4-methoxy-benzene 
• 142076-10-6 1-((E)-4-Benzenesulfonyl-3-methyl-1-nitromethyl-but-3-enyl)-4-methoxy-benzene 

Relevant articles and documents

Silver-catalyzed decarboxylative radical allylation of α,α-difluoroarylacetic acids for the construction of CF2-allyl bonds

An efficient silver-catalyzed method of decarboxylative radical allylation of α,α-difluoroarylacetic acids to build CF2-allyl bonds has been developed. Using allylsulfone as an allyl donor, α,α-difluorine substituted arylacetic acids bearing various functional groups are successfully allylated to access a series of 3-(α,α-difluorobenzyl)-1-propylene compounds in moderate to excellent yields in aqueous CH3CN solution under the mild conditions. Experimental studies disclosed that the α-fluorine substitution of arylacetic acid has a great influence on free radical activity and reactivity.

Palladium-catalyzed substitution of allylic alcohols with sulfinate salts: A synthesis of bicalutamide

A method is presented for the direct substitution of allylic alcohols with sodium arylsulfinates. The process involves a cooperative action of palladium catalysts, phenylboronic acid and titanium tetraisopropoxide. By taking advantage of this protocol, we achieved a concise synthesis of bicalutamide, an anti-androgen compound for treating prostate cancer.

Reciprocal-Activation Strategy for Allylic Sulfination with Unactivated Allylic Alcohols

A reciprocal-activation strategy for allylic sulfination with unactivated allylic alcohols was developed. In this reaction, the hydrogen bond interaction between allylic alcohols and sulfinic acids allowed for reciprocal activation, which enabled a dehydrative cross-coupling process to occur under mild reaction conditions. This reaction worked in an environmentally friendly manner, yielding water as the only byproduct. A variety of allylic sulfones could be obtained in good to excellent yields with wide functional group tolerance. In gram scale reactions, allylic sulfones could be conveniently isolated in high yield by filtration.