100239-05-2Relevant academic research and scientific papers
The Synthesis of Substituted thio>acetic Acids
Woulfe, Steven R.,Miller, Marvin J.
, p. 3133 - 3139 (2007/10/02)
The synthesis of substituted thio>acetic acids (6, thiamazins) is described.Various substituted 3(S)-(acylamino)-2-azetidinones were sulfenylated with tert-butyl (phtalimidothio)acetate.Deprotection of the tert-butyl ester with trifluoroacetic acid provided the title compounds.In sharp contrast to their oxygen analogues (oxamazins), the thiamazins were devoid of biological activity.
EFFICIENT N-SULFENYLATION OF 2-AZETIDINONES USING S-SUBSTITUTED THIOPHTHALIMIDES
Woulfe, Steven R.,Iwagami, Hisao,Miller, Marvin J.
, p. 3891 - 3894 (2007/10/02)
Reaction of N-unsubstituted β-lactams with various S-substituted thiophthalimides provides an efficient route to the corresponding N-thio-2-azetidinones.
