100245-06-5Relevant academic research and scientific papers
A cyclohexane spacer for phosphate receptors
Raposo, Cesar,Perez, Nieves,Almaraz, Marta,Mussons, Ma Luisa,Caballero, Ma Cruz,Moran, Joaquin R.
, p. 3255 - 3258 (1995)
A cyclohexane tricarboxyclic acid is shown to be a good spacer for phosphate guests. The combination of 8-aminochromenone-2-carboxamide groups with the cyclohexane spacer leads to a versatile receptor which sets six hydrogen bonds with either phosphonic a
A highly selective receptor for zwitterionic proline
Temprano, álvaro G.,Monleón, Laura M.,Rubio, Omayra H.,Rubio, Luis Simón,Pérez, Asunción B.,Sanz, Francisca,Morán, Joaquín R.
, p. 1325 - 1331 (2016)
A chiral chromane receptor has been synthesized which mimics the oxyanion hole of the enzymes. In this receptor H-bonds and cation-π interactions team up to generate an apolar host-guest complex with zwitterionic proline. This complex allows the extraction of only proline to a chloroform phase, while no other natural amino acids are extracted. Due to the chiral nature of the receptor, enantioselective extraction from the aqueous proline solution to a chloroform phase takes place. l-Proline provided an easy method to resolve the receptor racemic mixture, while anisotropic effects, NOE and CD studies revealed the absolute configuration of the receptor. Modelling studies also support the proposed structures. The presence of an oxyanion-hole motif in this structure was corroborated by X-ray diffraction studies.
Synthesis method of 2-hydroxyl-3-nitroacetophenone
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Paragraph 0018; 0021; 0025, (2017/04/27)
The invention provides a synthesis method of 2-hydroxyl-3-nitroacetophenone. Starting from p-tert-butylphenol, the synthesis method is used for synthesizing the 2-hydroxyl-3-nitroacetophenone through four-step reaction including the steps of esterification, Fries rearrangement, nitrification and disproportionation in sequence. Compared with the prior art, the synthesis method has the advantages that raw materials are easy to obtain and the cost is low; a product obtained by disproportionation reaction mainly comprises the p-tert-butylphenol and can be recycled, so that a few of wastes are generated and the synthesis method is clean and environment-friendly; after the reaction is finished, the product can be recycled after being simply filtered, so that the cost is reduced and the emission of the wastes is reduced; and the target product can be obtained in a high yield, and the total yield reaches 70% to 80%.
