100288-60-6

Upstream product

• 288-32-4 1H-imidazole 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 131089-35-5 methyl 6-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-α-D-mannopyranoside 
• 107033-46-5 (R)-(tert-butyldiphenylsilyloxy)methyloxirane 
• 106731-74-2 tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane 
• 244022-43-3 methyl 6-O-tert-butyldiphenylsilyl-2,3,4-tri-O-(4-methylbenzoyl)-1-thio-β-D-galactopyranoside 
• 151072-06-9 methyl 6-O-(tert-butyldiphenylsilyl)-1-thio-β-D-galactopyranoside 

Relevant academic research and scientific papers

Treatment Of Neurofibromatosis With Radicicol And Its Derivatives

The present invention provides compounds of formulae Ia, Ia′, IIa, IIa′, IIIa, IIIa′, IVa, or Va and the therapeutic use thereof. The present invention also includes methods of treating NF2-deficient or NF1-deficient cells or neurodegenerative diseases with radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia′, IIa, IIa′, IIIa, IIIa′, IVa, or Va. Furthermore, the present invention is directed to methods of inhibiting the growth of NF2-deficient or NF1-deficient tumors. The methods comprise contacting NF2-deficient or NF1-deficient tumor cells with radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia′, IIa, IIa′, IIIa, IIIa′, IVa, or Va. The present invention is also directed to the combinational use of radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia′, IIa, IIa′, IIIa, IIIa′, IVa, or Va with at least one additional active agent, such as one or more HSP90 inhibitors.

Morpholino-subunit combinatorial library and method

A method of generating a compound capable of interacting specifically with a selected macromolecular ligand is disclosed. The method involves contacting the ligand with a combinatorial library of oligomers composed of morpholino subunits with a variety of nucleobase and non-nucleobase side chains. Oligomer molecules that bind specifically to the receptor are isolated and their sequence of base moieties is determined. Also disclosed is a combinatorial library of oligomers useful in the method and novel morpholino-subunit polymer compositions.

Palladium catalyzed alkylative cyclization useful in synthesis of vitamin D and analogues

An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a substantially geometrically pure first precursor having the structure STR1 and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure STR2 where R2 hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.